Molecular structure of Efonidipine hydrochloride monoethanolate, CAS Number: 111011-76-8
Efonidipine hydrochloride monoethanolate (CAS 111011-76-8)
Application:
Efonidipine hydrochloride monoethanolate is a calcium channel protein inhibitor
CAS Number:
111011-76-8
Molecular Weight:
714.18
Molecular Formula:
C34H38N3O7P•HCl•C2H5OH
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Racemic efonidipine has both L-type and T-type calcium channel protein inhibitor activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.
Efonidipine hydrochloride monoethanolate (CAS 111011-76-8) References
- Effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1. | Tanaka, H., et al. 2010. Eur J Pharmacol. 649: 263-7. PMID: 20858482
- Determination of efonidipine in human plasma by LC-MS/MS for pharmacokinetic applications. | Liu, M., et al. 2015. J Pharm Biomed Anal. 103: 1-6. PMID: 25462114
- A chiral LC-MS/MS method for the stereospecific determination of efonidipine in human plasma. | Liu, M., et al. 2016. J Pharm Biomed Anal. 122: 35-41. PMID: 26845200
- High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells. | Shimada, H., et al. 2017. FEBS Open Bio. 7: 1410-1421. PMID: 28904869
- Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells. | Klec, C., et al. 2019. Cell Physiol Biochem. 52: 57-75. PMID: 30790505
- Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. | Diamantopoulou, E., et al. 2019. Elife. 8: PMID: 31180326
- A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease. | Alalam, H., et al. 2021. mSystems. 6: e0108721. PMID: 34812651
Inhibitor of:
Calcium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Efonidipine hydrochloride monoethanolate, 5 mg | sc-364486 | 5 mg | $46.00 | |||
Efonidipine hydrochloride monoethanolate, 25 mg | sc-364486A | 25 mg | $255.00 |