EF-CAB1 Antibody (B-2): sc-515554
- EF-CAB1 Antibody (B-2) is a mouse monoclonal IgG1 κ EF-CAB1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 187-210 at the C-terminus of EF-CAB1 of human origin
- EF-CAB1 Antibody (B-2) is recommended for detection of EF-CAB1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-EF-CAB1 Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for EF-CAB1 Antibody (B-2) for WB applications. These reagents are now offered in bundles with EF-CAB1 Antibody (B-2) (see ordering information below).
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EF-CAB1 Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects EF-CAB1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-EF-CAB1 antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EF-CAB1, which stands for EF-hand calcium-binding domain-containing peptide protein 1, is encoded by a gene located on chromosome 8′s long arm and produces a 211 amino acid protein with three EF-hand domains. These helix-loop-helix structures are essential for calcium binding, a crucial process in numerous cellular functions, including muscle contraction, neurotransmitter release, and cell signaling pathways. EF-CAB1′s calcium-binding capability suggests a potential role in modulating these processes, making EF-CAB1 valuable for understanding calcium signaling in various physiological and pathological contexts. Chromosome 8, where EF-CAB1 resides, is involved in several genetic disorders and cancers, highlighting EF-CAB1′s significance in disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EF-CAB1 Antibody (B-2) References:
- Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases. | Beyer, V., et al. 2005. Cancer Genet Cytogenet. 160: 97-119. PMID: 15993266
- Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. | Paulsson, K. and Johansson, B. 2007. Pathol Biol (Paris). 55: 37-48. PMID: 16697122
- Deciphering function and mechanism of calcium-binding proteins from their evolutionary imprints. | Morgan, RO., et al. 2006. Biochim Biophys Acta. 1763: 1238-49. PMID: 17092580
- Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3. | Lakowski, TM., et al. 2007. Protein Sci. 16: 1119-32. PMID: 17473011
- Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3. | Lakowski, TM., et al. 2007. Biochemistry. 46: 8525-36. PMID: 17595060
- Essential dynamics of helices provide a functional classification of EF-hand proteins. | Capozzi, F., et al. 2007. J Proteome Res. 6: 4245-55. PMID: 17935310
- Free-energy linkage between folding and calcium binding in EF-hand proteins. | Suarez, MC., et al. 2008. Biophys J. 95: 4820-8. PMID: 18689462
- Rare translocations involving chromosome band 8p11 in myeloid neoplasms. | Lee, SG., et al. 2008. Cancer Genet Cytogenet. 186: 127-9. PMID: 18940479
- The genetic background of craniosynostosis syndromes. | Heutink, P., et al. 1995. Eur J Hum Genet. 3: 312-23. PMID: 8556306
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EF-CAB1 Antibody (B-2) | sc-515554 | 200 µg/ml | $322.00 | |||
EF-CAB1 Antibody (B-2): m-IgG Fc BP-HRP Bundle | sc-531412 | 200 µg Ab; 10 µg BP | $361.00 | |||
EF-CAB1 Antibody (B-2): m-IgGκ BP-HRP Bundle | sc-525097 | 200 µg Ab, 40 µg BP | $361.00 | |||
EF-CAB1 Antibody (B-2): m-IgG1 BP-HRP Bundle | sc-544538 | 200 µg Ab; 20 µg BP | $361.00 | |||
EF-CAB1 Antibody (B-2) AC | sc-515554 AC | 500 µg/ml, 25% agarose | $424.00 | |||
EF-CAB1 Antibody (B-2) HRP | sc-515554 HRP | 200 µg/ml | $322.00 | |||
EF-CAB1 Antibody (B-2) FITC | sc-515554 FITC | 200 µg/ml | $336.00 | |||
EF-CAB1 Antibody (B-2) PE | sc-515554 PE | 200 µg/ml | $349.00 | |||
EF-CAB1 Antibody (B-2) Alexa Fluor® 488 | sc-515554 AF488 | 200 µg/ml | $364.00 | |||
EF-CAB1 Antibody (B-2) Alexa Fluor® 546 | sc-515554 AF546 | 200 µg/ml | $364.00 | |||
EF-CAB1 Antibody (B-2) Alexa Fluor® 594 | sc-515554 AF594 | 200 µg/ml | $364.00 | |||
EF-CAB1 Antibody (B-2) Alexa Fluor® 647 | sc-515554 AF647 | 200 µg/ml | $364.00 | |||
EF-CAB1 Antibody (B-2) Alexa Fluor® 680 | sc-515554 AF680 | 200 µg/ml | $364.00 | |||
EF-CAB1 Antibody (B-2) Alexa Fluor® 790 | sc-515554 AF790 | 200 µg/ml | $364.00 | |||
EF-CAB1 (B-2) Neutralizing Peptide | sc-515554 P | 100 µg/0.5 ml | $69.00 |