EED Antibody (3B12): sc-293203
- EED Antibody (3B12) is a mouse monoclonal IgG2a κ EED antibody, cited in 2 publications, provided at 100 µg/ml
- raised against amino acids 342-441 of EED of human origin
- recommended for detection of EED of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EED Antibody (3B12). This work is in progress.
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EED Antibody (3B12) is a mouse monoclonal IgG2a kappa light chain antibody that detects EED protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-EED antibody (3B12) is available as the non-conjugated format. EED protein, or embryonic ectoderm development protein, plays a crucial role in gene expression regulation through involvement in Polycomb-group (PcG) complexes, which maintain transcriptional repression of target genes across cell divisions. This function is vital for cellular memory, allowing cells to remember their identity and maintain stable gene expression patterns during development and differentiation. Human EED protein is highly conserved, sharing 99.5% identity with its mouse counterpart, and features seven WD repeats that facilitate protein-protein interactions, underscoring importance in multiprotein complex assembly. EED interacts specifically with histone deacetylase (HDAC) proteins, highlighting a role in chromatin remodeling and gene silencing. The presence of two human EED transcripts, resulting in two isoforms of 535 and 494 amino acids, adds complexity to regulatory functions, making EED (3B12) monoclonal antibody a valuable tool for researchers studying gene regulation and epigenetic mechanisms in various biological contexts.
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EED Antibody (3B12) References:
- PRC2-complex related dysfunction in overgrowth syndromes: A review of EZH2, EED, and SUZ12 and their syndromic phenotypes. | Cyrus, S., et al. 2019. Am J Med Genet C Semin Med Genet. 181: 519-531. PMID: 31724824
- Polycomb Repressive Complex 2 Modulation through the Development of EZH2-EED Interaction Inhibitors and EED Binders. | Tomassi, S., et al. 2021. J Med Chem. 64: 11774-11797. PMID: 34351144
- Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment. | Cook, N., et al. 2021. Curr Top Med Chem. 21: 2771-2777. PMID: 34544341
- Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs. | Zhao, Y., et al. 2022. Eur J Med Chem. 231: 114144. PMID: 35093670
- An overview of the development of EED inhibitors to disable the PRC2 function. | Liu, KL., et al. 2022. RSC Med Chem. 13: 39-53. PMID: 35224495
- Loss of microglial EED impairs synapse density, learning, and memory. | Wang, YY., et al. 2022. Mol Psychiatry. 27: 2999-3009. PMID: 35484239
- The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. | Zhang, SF., et al. 2022. Stem Cell Reports. 17: 2064-2080. PMID: 35931079
- Targeting EED as a key PRC2 complex mediator toward novel epigenetic therapeutics. | Bao, Q., et al. 2024. Drug Discov Today. 29: 103986. PMID: 38642703
- An EED/PRC2-H19 Loop Regulates Cerebellar Development. | Liu, PP., et al. 2025. Adv Sci (Weinh). 12: e2403591. PMID: 39498824
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EED Antibody (3B12) | sc-293203 | 100 µg/ml | $322.00 |