Date published: 2025-12-17

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EED Inhibitors

EED inhibitors represent a class of small molecules that specifically target the Enhancer of Zeste Homolog 2 (EZH2) and Embryonic Ectoderm Development (EED) proteins within the Polycomb Repressive Complex 2 (PRC2). The PRC2 complex plays a pivotal role in epigenetic regulation, primarily by catalyzing the methylation of histone proteins, thereby modulating gene expression. EED, one of the core components of PRC2, is crucial for its stability and function. EED inhibitors are designed to disrupt the interactions between EED and its binding partners, specifically the WD40 domain of EED that recognizes histone marks and other PRC2 components, particularly EZH2. This interference leads to a compromised PRC2 complex, resulting in the reduced trimethylation of histone H3 at lysine 27 (H3K27me3), which is a hallmark of PRC2-mediated epigenetic repression. The mechanism of action of EED inhibitors involves competitive binding to the WD40 domain of EED, preventing its engagement with histone tails and other essential proteins, thus compromising the integrity of PRC2. By disrupting the PRC2 complex, EED inhibitors can influence gene expression patterns and impacts various cellular processes. While their primary utility lies in the realm of research and understanding epigenetic regulation, EED inhibitors hold significant promise in elucidating the intricate molecular mechanisms underlying gene expression control. The development and study of EED inhibitors are essential not only for advancing our understanding of epigenetics but also for exploring applications in diverse fields.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine may inhibit EED expression by incorporating into DNA and disrupting its methylation status, which could potentially alter the chromatin structure and reduce EED transcription.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

5-Aza-2′-Deoxycytidine is a cytidine analog that may reduce EED expression by inhibiting DNA methyltransferases, resulting in hypomethylation of the EED promoter region and suppression of its transcription.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A, another histone deacetylase inhibitor, may reduce EED expression by promoting a more accessible chromatin state and hindering the binding of transcriptional repressors to the EED promoter.

RG 108

48208-26-0sc-204235
sc-204235A
10 mg
50 mg
$128.00
$505.00
2
(1)

RG108, a DNA methyltransferase inhibitor, has the potential to lower EED expression by decreasing the methylation levels of its promoter, fostering a transcriptionally active chromatin state.

GSK126

1346574-57-9sc-490133
sc-490133A
sc-490133B
1 mg
5 mg
10 mg
$90.00
$238.00
$300.00
(0)

GSK126, an EZH2 inhibitor, has the potential to reduce EED expression indirectly by inhibiting PRC2 activity, resulting in decreased H3K27me3 levels and elevated gene expression.

Chaetocin

28097-03-2sc-200893
200 µg
$120.00
5
(1)

Chaetocin, a histone methyltransferase inhibitor, may lower EED expression by inhibiting SUV39H1, leading to a reduction in H3K9 methylation and an increase in gene expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin is a flavonoid that may reduce EED expression by acting as an antioxidant, decreasing oxidative stress, and potentially modulating signaling pathways involved in EED transcription.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein, a soy isoflavone, has the potential to reduce EED expression through its estrogenic activity, possibly influencing hormonal signaling pathways that regulate EED transcription.

BIX01294 hydrochloride

1392399-03-9sc-293525
sc-293525A
sc-293525B
1 mg
5 mg
25 mg
$36.00
$110.00
$400.00
(1)

BIX-01294 is an inhibitor of G9a and GLP histone methyltransferases, and it may lower EED expression by decreasing H3K9 methylation, fostering a more open chromatin state and enhancing gene transcription.