EDIL3 Antibody (4C9): sc-293337

EDIL3 Antibody (4C9) is a mouse monoclonal IgG2a kappa light chain antibody that detects EDIL3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-EDIL3 antibody (4C9) is available as a non-conjugated format. EDIL3, also known as developmentally-regulated endothelial cell locus 1 protein or integrin-binding protein DEL1, is a 480 amino acid secreted glycoprotein that plays a crucial role in angiogenesis, particularly during solid tumor formation. EDIL3 is expressed in embryonic endothelial cells and functions as a ligand for Integrin αV/β3, promoting endothelial cell adhesion through an autocrine angiogenic signaling pathway. This interaction is vital for vascular morphogenesis during embryonic development and is essential for the remodeling of vessel walls. EDIL3 contains three EGF-like domains and two F5/8 type C domains, and exists as two alternatively spliced isoforms encoded by a gene located on human chromosome 5q14.3. EDIL3′s ability to facilitate endothelial cell interactions and involvement in angiogenesis underscore its importance in both developmental biology and cancer research, making anti-EDIL3 antibody (4C9) a valuable tool for studying these processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

EDIL3 Antibody (4C9) References:

1. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3.  |  Penta, K., et al. 1999. J Biol Chem. 274: 11101-9. PMID: 10196194
2. Del1: a new protein in the superficial layer of articular cartilage.  |  Pfister, BE., et al. 2001. Biochem Biophys Res Commun. 286: 268-73. PMID: 11500032
3. Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3).  |  Rezaee, M., et al. 2002. Am J Physiol Heart Circ Physiol. 282: H1924-32. PMID: 11959660
4. The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation.  |  Aoka, Y., et al. 2002. Microvasc Res. 64: 148-61. PMID: 12074641
5. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1.  |  Zhong, J., et al. 2003. J Clin Invest. 112: 30-41. PMID: 12840057
6. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.  |  Choi, EY., et al. 2008. Science. 322: 1101-4. PMID: 19008446
7. Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor.  |  Hidai, C., et al. 1998. Genes Dev. 12: 21-33. PMID: 9420328

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EDIL3 Antibody (4C9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-EDIL3 Antibody (4C9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EDIL3 Antibody (4C9) Specifications

Alternate Product Name: EDIL3

Product Clone Name: 4C9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 101-199

Epitope Target: EDIL3

Epitope Species: human

Product Reactivity/Detection: EDIL3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for EDIL3 Antibody (4C9): N/A