ECP Antibody (C3): sc-517595

ECP Antibody (C3) is a mouse monoclonal IgG2b antibody that detects ECP protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-ECP antibody (C3) is available as the non-conjugated form. Eosinophil cationic protein (ECP), also known as RNS3 or RNASE3, is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP is primarily localized in the granule matrix of eosinophils, which are crucial for the immune response, particularly in combating parasitic infections and mediating allergic reactions. The localization of ECP within eosinophil granules enables rapid release of this cytotoxic protein upon activation, allowing a swift immune response. ECP functions as a cytotoxin, neurotoxin, and helminthotoxin, exhibiting anti-parasitic, antibacterial, and ribonucleolytic activities. ECP has been implicated in the neurotoxic effects associated with the Gordon phenomenon, a syndrome characterized by ataxia, muscular rigidity, paralysis, and tremor, which can be fatal. Elevated levels of ECP are often observed in conditions of eosinophilic inflammation, such as active asthma and other allergic diseases, making ECP a valuable marker for diagnosing and monitoring these conditions.

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ECP Antibody (C3) References:

1. Eosinophil cationic protein: is it useful in asthma? A systematic review.  |  Koh, GC., et al. 2007. Respir Med. 101: 696-705. PMID: 17034998
2. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.  |  Munthe-Kaas, MC., et al. 2007. Allergy. 62: 429-36. PMID: 17362255
3. Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans.  |  Torrent, M., et al. 2008. Biochemistry. 47: 3544-55. PMID: 18293932
4. Characterization of molecular interactions between eosinophil cationic protein and heparin.  |  Fan, TC., et al. 2008. J Biol Chem. 283: 25468-25474. PMID: 18593710
5. [Evaluation of eosinophil cationic protein levels with clinical symptoms and laboratory findings of patients with cystic echinococcosis].  |  Cicioğlu Aridoğan, B., et al. 2009. Mikrobiyol Bul. 43: 285-92. PMID: 19621614
6. Eosinophils and cellular injury: the Gordon phenomenon as a model.  |  Fredens, K., et al. 1985. N Engl Reg Allergy Proc. 6: 346-51. PMID: 3916590
7. The Gordon phenomenon induced by the eosinophil cationic protein and eosinophil protein X.  |  Fredens, K., et al. 1982. J Allergy Clin Immunol. 70: 361-6. PMID: 7130551
8. Recombinant human eosinophil cationic protein. Ribonuclease activity is not essential for cytotoxicity.  |  Rosenberg, HF. 1995. J Biol Chem. 270: 7876-81. PMID: 7713881
9. Toxicity of an antitumor ribonuclease to Purkinje neurons.  |  Newton, DL., et al. 1994. J Neurosci. 14: 538-44. PMID: 8301353

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ECP Antibody (C3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ECP Antibody (C3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ECP Antibody (C3) Specifications

Alternate Product Name: ECP

Product Clone Name: C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b lambda light chain

Amino Acids:

Epitope Target: ECP

Epitope Species: human

Product Reactivity/Detection: ECP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2b lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 5% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ECP Antibody (C3): N/A