Econazole nitrate salt (CAS 24169-02-6)

Econazole nitrate salt, identified by the CAS number 24169-02-6, is a synthetic compound belonging to the imidazole class of antifungals. Its primary mode of action involves disrupting the synthesis of ergosterol, a vital component of fungal cell membranes. By inhibiting the enzyme lanosterol 14α-demethylase, econazole interferes with the conversion of lanosterol to ergosterol, leading to the accumulation of toxic intermediates and a decrease in ergosterol levels within the cell membrane. This disruption compromises the integrity and functionality of the fungal membrane, resulting in increased permeability and eventual cell death. In research settings, econazole nitrate salt has been extensively used to study fungal physiology and the biochemical pathways involved in cell membrane synthesis. Its role in disrupting membrane integrity makes it a valuable tool for exploring membrane-associated processes and the adaptive responses of fungi to membrane stress. Furthermore, econazole has been utilized in studies aimed at understanding the development of resistance to antifungal agents, particularly within the imidazole class. These investigations help clarify the molecular mechanisms by which fungi evolve resistance and assist in the development of strategies to counteract these resistance mechanisms in pathogenic fungal species.