Molecular structure of Echinocandin B, CAS Number: 54651-05-7
Echinocandin B (CAS 54651-05-7)
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Alternate Names:
A 30912; A 22082; SL 7810F
Application:
Echinocandin B is a potent antifungal that acts by inhibition of the synthesis of β(1,3)-D-glucan
CAS Number:
54651-05-7
Molecular Weight:
1060.40
Molecular Formula:
C52H81N7O16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Echinocandin B is a cyclic hexapeptide echinocandin found in Aspergillus nidulans var. echinulatus. In research applications it has shown anti-yeast activity by targeting fungal cell walls. It acts as an inhibitor of 1,3-β glucan synthase, a key enzyme in the synthesis of beta-1,3-glucan, which is a component of the fungal cell wall. The compound may act to halt the growth of C. albicans in laboratory applications, evidenced by its ability to prevent the incorporation of glucose into the glucan structure of S. cerevisiae spheroplasts in a concentration-dependent fashion.
Echinocandin B (CAS 54651-05-7) References
- The echinocandin B producer fungus Aspergillus nidulans var. roseus ATCC 58397 does not possess innate resistance against its lipopeptide antimycotic. | Tóth, V., et al. 2012. Appl Microbiol Biotechnol. 95: 113-22. PMID: 22555909
- Efficient bioconversion of echinocandin B to its nucleus by overexpression of deacylase genes in different host strains. | Shao, L., et al. 2013. Appl Environ Microbiol. 79: 1126-33. PMID: 23220968
- Preparative separation of echinocandin B from Aspergillus nidulans broth using macroporous resin adsorption chromatography. | Zou, SP., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 978-979: 111-7. PMID: 25541471
- Enhancement of Echinocandin B Production by a UV- and Microwave-Induced Mutant of Aspergillus nidulans with Precursor- and Biotin-Supplying Strategy. | Hu, ZC., et al. 2016. Appl Biochem Biotechnol. 179: 1213-26. PMID: 27039401
- Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster. | Hüttel, W., et al. 2016. BMC Genomics. 17: 570. PMID: 27502607
- Cryptic Production of trans-3-Hydroxyproline in Echinocandin B Biosynthesis. | Mattay, J., et al. 2018. Appl Environ Microbiol. 84: PMID: 29352089
- Functional redundancy in Echinocandin B in-cluster transcription factor ecdB of Emericella rugulosa NRRL 11440. | Kumar, A., et al. 2018. Biotechnol Rep (Amst). 19: e00264. PMID: 29992098
- Deacylation of Echinocandin B by Streptomyces species: a novel method for the production of Echinocandin B nucleus. | Shivakumar, MC., et al. 2019. 3 Biotech. 9: 412. PMID: 31696017
- Enhancing Catalytic Efficiency of an Actinoplanes utahensis Echinocandin B Deacylase through Random Mutagenesis and Site-Directed Mutagenesis. | Cheng, YN., et al. 2020. Appl Biochem Biotechnol. 190: 1257-1270. PMID: 31741208
- Mutagenesis of echinocandin B overproducing Aspergillus nidulans capable of using starch as main carbon source. | Hu, ZC., et al. 2020. Prep Biochem Biotechnol. 50: 745-752. PMID: 32125248
- Effects of methyl oleate and microparticle-enhanced cultivation on echinocandin B fermentation titer. | Niu, K., et al. 2020. Bioprocess Biosyst Eng. 43: 2009-2015. PMID: 32557175
- The synthesis and activity evaluation of N-acylated analogs of echinocandin B with improved solubility and lower toxicity. | Zhu, B., et al. 2020. J Pept Sci. 26: e3278. PMID: 32743839
- Effects of lipids and surfactants on the fermentation production of echinocandin B by Aspergillus nidulans. | Niu, K., et al. 2021. J Appl Microbiol. 131: 2849-2860. PMID: 33987908
- Functional expression of an echinocandin B deacylase from Actinoplanes utahensis in Escherichia coli. | Zou, SP., et al. 2021. Int J Biol Macromol. 187: 850-857. PMID: 34339787
- Investigation of the enhancement for Echinocandin B fermentation with methyl oleate from transcription level. | Niu, K., et al. 2023. Bioprocess Biosyst Eng. 46: 1045-1052. PMID: 37253987
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Echinocandin B, 1 mg | sc-362020 | 1 mg | $210.00 | |||
Echinocandin B, 5 mg | sc-362020A | 5 mg | $1000.00 | |||
Echinocandin B, 50 mg | sc-362020B | 50 mg | $8340.00 | |||
Echinocandin B, 100 mg | sc-362020C | 100 mg | $16000.00 |