EBV EBNA-1 Antibody (3EB9): sc-81585

EBV EBNA-1 Antibody (3EB9) is a mouse monoclonal IgG1 antibody that detects EBV EBNA-1 in Epstein-Barr virus (EBV) by western blotting (WB) and immunoprecipitation (IP). EBV EBNA-1 plays a crucial role in the life cycle of the Epstein-Barr virus, as EBV EBNA-1 is essential for the synthesis and maintenance of the viral genome, thereby facilitating the persistence of the virus within host cells. EBV EBNA-1 is expressed in all EBV-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, highlighting its importance in oncogenesis. EBV EBNA-1′s ability to bind to the viral genome ensures that the virus can replicate and persist in the host, which is critical for the development of EBV-related malignancies. Additionally, EBV EBNA-1 interacts with various cellular proteins, influencing cellular pathways that promote cell survival and proliferation, further underscoring its significance in both viral pathogenesis and cancer biology. Anti-EBV EBNA-1 antibody (3EB9) is an invaluable tool for researchers studying the mechanisms of EBV infection and its associated diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

EBV EBNA-1 Antibody (3EB9) References:

1. Epstein-Barr virus nuclear antigen-1 and Myc cooperate in lymphomagenesis.  |  Drotar, ME., et al. 2003. Int J Cancer. 106: 388-95. PMID: 12845679
2. Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice.  |  Kang, MS., et al. 2005. Proc Natl Acad Sci U S A. 102: 820-5. PMID: 15640350
3. Autorepression of Epstein-Barr virus nuclear antigen 1 expression by inhibition of pre-mRNA processing.  |  Yoshioka, M., et al. 2008. J Virol. 82: 1679-87. PMID: 18077719
4. The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.  |  Gruhne, B., et al. 2009. Proc Natl Acad Sci U S A. 106: 2313-8. PMID: 19139406
5. A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).  |  Rubicz, R., et al. 2013. PLoS Genet. 9: e1003147. PMID: 23326239
6. Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription.  |  Chen, YL., et al. 2014. Proc Natl Acad Sci U S A. 111: 243-8. PMID: 24344309
7. Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.  |  Nakada, R., et al. 2017. Biochem Biophys Res Commun. 484: 113-117. PMID: 28104399
8. NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression.  |  Verhoeven, RJA., et al. 2018. Cancers (Basel). 10: PMID: 29659505
9. The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes.  |  Boudreault, S., et al. 2019. Virol J. 16: 29. PMID: 30832682
10. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma.  |  Paudel, S., et al. 2022. Clin Cancer Res. 28: 5221-5230. PMID: 36165913

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.