EBV Bcl-2 Antibody (5E270): sc-71022

EBV Bcl-2 Antibody (5E270) is a mouse monoclonal IgG1 antibody that detects the EBV Bcl-2 protein of Epstein-Barr virus origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-EBV Bcl-2 antibody (5E270) is available as the non-conjugated format. The Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpesvirus family and is one of the most prevalent human viruses, infecting approximately 90% of the global population. EBV primarily targets B cells and, while often asymptomatic, can lead to infectious mononucleosis, which presents with symptoms such as fatigue, fever, sore throat, and muscle aches. The Bcl-2 protein plays a crucial role as an anti-apoptotic regulator of the cell cycle, and Bcl-2 expression is significantly elevated in EBV-positive lymphomas, where Bcl-2 may contribute to oncogenesis. Notably, during the early lytic cycle of EBV infection, the virus expresses the BHRF1 gene, which encodes a viral Bcl-2 homolog. This transmembrane protein is essential for inhibiting apoptosis during EBV infection, thereby enhancing the production of viral particles and promoting the establishment of viral persistence. EBV Bcl-2 (5E270) antibody effectively detects this critical protein, making EBV Bcl-2 monoclonal antibody (5E270) an invaluable tool for researchers studying the mechanisms of EBV pathogenesis and associated malignancies.

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EBV Bcl-2 Antibody (5E270) References:

1. Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2.  |  Howell, M., et al. 2005. BMC Microbiol. 5: 6. PMID: 15691372
2. Bcl-2 and c-Myc co-operate in the Epstein-Barr virus-immortalized human B-cell line GM607 but do not confer tumorigenicity.  |  Tomlin, JL., et al. 2005. Leuk Lymphoma. 46: 581-92. PMID: 16019487
3. Cell-cycle regulators, bcl-2 and NF-kappaB in Epstein-Barr virus-positive gastric carcinomas.  |  Chang, MS., et al. 2005. Int J Oncol. 27: 1265-72. PMID: 16211221
4. Expression of Etk/Bmx tyrosine kinase in the tumorigenicity of nasopharyngeal epithelium and its relation with EB virus infection and the apoptosis-related protein Bcl-2.  |  Guo, L., et al. 2006. Cancer Lett. 232: 255-61. PMID: 16458122
5. Systemic Bcl-2 antisense oligodeoxynucleotide in combination with cisplatin cures EBV+ nasopharyngeal carcinoma xenografts in SCID mice.  |  Lacy, J., et al. 2006. Int J Cancer. 119: 309-16. PMID: 16477627
6. Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival.  |  Li, LY., et al. 2006. J Gen Virol. 87: 2869-2878. PMID: 16963744
7. Expression of bcl-2 protein and transcription of the Epstein-Barr virus bcl-2 homologue BHRF-1 in Hodgkin's disease: implications for different pathogenic mechanisms.  |  Jiwa, NM., et al. 1995. Histopathology. 26: 547-53. PMID: 7665145
8. The Epstein-Barr virus gene BHRF1, a homologue of the cellular oncogene Bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs.  |  McCarthy, NJ., et al. 1996. Adv Exp Med Biol. 406: 83-97. PMID: 8910674
9. BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates.  |  Khanim, F., et al. 1997. J Gen Virol. 78 (Pt 11): 2987-99. PMID: 9367386

The preferred Bcl-2 antibody is Bcl-2 Antibody (C-2): sc-7382.