Ebola virus VP40 Antibody (FE18): sc-51872

Ebola virus VP40 Antibody (FE18) is a mouse monoclonal IgG2a antibody that detects the Ebola virus VP40 protein of Ebola virus origin by western blotting (WB). Anti-Ebola virus VP40 antibody (FE18) is available as a non-conjugated format, specifically designed to aid in the study of this critical viral protein. VP40 protein plays a vital role in the assembly and budding of the Ebola virus, functioning as a matrix protein that facilitates the formation of viral particles. VP40 interacts with viral glycoprotein and nucleoprotein, thereby influencing the morphology and infectivity of the virus. Understanding VP40 function is crucial for developing therapeutic strategies and vaccines against Ebola virus, as VP40 is a key target for antiviral interventions. Ebola virus is an enveloped, negative-stranded RNA virus belonging to the Filoviridae family, characterized by unique morphology and ability to cause severe viral hemorrhagic fever. Ebola virus genome encodes seven structural proteins, including major nucleoprotein, glycoprotein, and L protein, alongside VP40, which is essential for viral life cycle. Ebola virus VP40 (FE18) monoclonal antibody enables deeper insights into mechanisms of Ebola virus pathogenesis and contributes to ongoing efforts to combat this deadly virus.

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Ebola virus VP40 Antibody (FE18) References:

1. Contribution of ebola virus glycoprotein, nucleoprotein, and VP24 to budding of VP40 virus-like particles.  |  Licata, JM., et al. 2004. J Virol. 78: 7344-51. PMID: 15220407
2. Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever.  |  Bray, M. and Geisbert, TW. 2005. Int J Biochem Cell Biol. 37: 1560-6. PMID: 15896665
3. Ebola virus VP40 late domains are not essential for viral replication in cell culture.  |  Neumann, G., et al. 2005. J Virol. 79: 10300-7. PMID: 16051823
4. Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function.  |  Wahl-Jensen, VM., et al. 2005. J Virol. 79: 10442-50. PMID: 16051836
5. Functional mapping of the nucleoprotein of Ebola virus.  |  Watanabe, S., et al. 2006. J Virol. 80: 3743-51. PMID: 16571791
6. Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level.  |  Alazard-Dany, N., et al. 2006. J Gen Virol. 87: 1247-1257. PMID: 16603527
7. Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling.  |  Cárdenas, WB., et al. 2006. J Virol. 80: 5168-78. PMID: 16698997
8. Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology.  |  Johnson, RF., et al. 2006. Virol J. 3: 31. PMID: 16719918
9. Molecular determinants of Ebola virus virulence in mice.  |  Ebihara, H., et al. 2006. PLoS Pathog. 2: e73. PMID: 16848640

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ebola virus VP40 Antibody (FE18) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ebola virus VP40 Antibody (FE18) Specifications

Alternate Product Name: Ebola virus VP40

Product Clone Name: FE18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Ebola virus VP40 VP40

Epitope Species: Ebola virus

Product Reactivity/Detection: VP40

Species Reactivity/Detection: Ebola virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Ebola virus VP40 Antibody (FE18): N/A