Molecular structure of Ebelactone A, CAS Number: 76808-16-7
Ebelactone A (CAS 76808-16-7)
Alternate Names:
3,11-Dihydroxy-2,4,6,8,10,12-hexamethyl-9-oxo-6-tetradecenoic acid 1,3-lactone
Application:
Ebelactone A is an inhibitor of esterase, formyl methionine aminopeptidase, and acylpeptide hydrolase
CAS Number:
76808-16-7
Purity:
≥99%
Molecular Weight:
338.48
Molecular Formula:
C20H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ebelactone A, a diterpene lactone naturally found in the root barks of Ebenus species. Its chemical structure reveals a cyclic diterpene lactone with an oxygen bridge linking C-3 and C-17, along with an additional oxygen bridge between C-2 and C-18. This compound exhibits exceptional stability. Though the precise mechanism of action of ebelactone A remains partially elusive, it is believed to operate through the modulation of enzymes and proteins. Particularly, ebelactone A hinders the activity of cyclooxygenase-2 (COX-2), while activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a transcription factor.
Ebelactone A (CAS 76808-16-7) References
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- Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone. | Wyatt, MA., et al. 2013. J Antibiot (Tokyo). 66: 421-30. PMID: 23801186
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Inhibitor of:
Aminopeptidase, APEH, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ebelactone A, 1 mg | sc-203035 | 1 mg | $98.00 |