E6 Berbamine (CAS 114784-59-7)
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E6 Berbamine is a potent and selective antagonist of calmodulin (CaM), known for its ability to disrupt the activity of calmodulin-dependent enzymes. It inhibits myosin light chain kinase (MLCK) with an IC50 value of 8 µM and a Ki of 0.95 µM, indicating its efficacy in inhibiting MLCK activity. Furthermore, E6 Berbamine may act to significantly inhibit phosphodiesterase 1A with an IC50 of 0.53 µM, showcasing its broad-spectrum inhibition of CaM-dependent processes. Additionally, it is effective against P-glycoprotein (P-gp) activity, not only in purified primary cultured rat brain microvessel endothelial cells at 10 µM but also in vascular endothelial cells, highlighting its potential in modulating blood-brain barrier permeability. E6 Berbamine also extends its inhibitory effects to α3-containing neuronal nicotinic acetylcholine receptors (α3-nAChRs).
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E6 Berbamine, 10 mg | sc-221573 | 10 mg | $127.00 | |||
E6 Berbamine, 50 mg | sc-221573A | 50 mg | $464.00 |