E/Z Ajoene (CAS 92285-01-3)

E/Z Ajoene represents a pair of organosulfur compounds found in garlic (Allium sativum), characterized by their distinct geometric isomers: E-ajoene (trans-ajoene) and Z-ajoene (cis-ajoene). These compounds are formed from the chemical reaction of allicin, the primary bioactive component in freshly crushed garlic cloves, under certain conditions. Ajoene exhibits a unique mechanism of action that involves modulation of various biological pathways, primarily attributed to its ability to interfere with molecular signaling and inhibit enzyme activities involved in cellular processes. The E and Z isomers, while chemically similar, may exhibit differences in biological activity due to the spatial orientation of their functional groups, influencing their interaction with biological molecules. The dual isomeric nature of ajoene allows scientists to investigate the structure-activity relationships (SAR) within molecular biology, providing insights into how slight changes in molecular geometry can impact biological efficacy and specificity.