E-Selectin/CD62E/SELE Antibody (UZ6): sc-59766
- E-Selectin/CD62E/SELE Antibody (UZ6) is a rat monoclonal IgG2b, cited in 2 publications, provided at 200 µg/ml
- raised against LPS-activated mIEND1 cells expressing E selectin at their cell surface of mouse origin
- recommended for detection of E-Selectin of mouse origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for E-Selectin/CD62E/SELE Antibody (UZ6). This work is in progress.
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E-Selectin Antibody (UZ6) is a rat monoclonal IgG2b antibody that detects E-Selectin in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). E-Selectin, also known as ELAM-1 or CD62E, is a crucial adhesion molecule expressed on the surface of endothelial cells, particularly when stimulated by cytokines during inflammatory responses. E-Selectin′s primary function is to mediate the adhesion of leukocytes to the vascular endothelium, facilitating their migration to sites of inflammation. This process is vital for the immune response, as E-Selectin allows immune cells to exit the bloodstream and reach areas of tissue damage or infection. E-Selectin′s ability to interact with specific carbohydrates on leukocytes underscores E-Selectin′s importance in regulating immune cell trafficking and maintaining homeostasis within the vascular system. Anti-E-Selectin antibody (UZ6) is an essential tool for researchers studying inflammation, immune responses, and related pathologies, providing insights into the mechanisms of leukocyte recruitment and the role of endothelial cells in these processes.
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E-Selectin/CD62E/SELE Antibody (UZ6) References:
- E-selectin up-regulation allows for targeted drug delivery in prostate cancer. | Bhaskar, V., et al. 2003. Cancer Res. 63: 6387-94. PMID: 14559828
- Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles. | Spivak, I., et al. 2016. Mol Imaging Biol. 18: 180-90. PMID: 26391990
- E-selectin and sICAM-1, biomarkers of endothelial function, predict recurrence of venous thromboembolism. | Dzikowska-Diduch, O., et al. 2017. Thromb Res. 157: 173-180. PMID: 28780342
- E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone. | Price, TT. and Sipkins, DA. 2017. Mol Cell Oncol. 4: e1214771. PMID: 28868340
- Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy. | Muz, B., et al. 2019. Blood Cancer J. 9: 68. PMID: 31431613
- Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019. | Oliva, A., et al. 2021. J Clin Med. 10: PMID: 34501466
- The presence of E-selectin in the myocardium indicates a sustained inflammatory reaction in patients with dilated cardiomyopathy. | Reichman-Warmusz, E., et al. 2022. Pathol Res Pract. 232: 153845. PMID: 35334367
- E-selectin supports neutrophil rolling in vitro under conditions of flow. | Abbassi, O., et al. 1993. J Clin Invest. 92: 2719-30. PMID: 7504692
- Creation and characterization of E-selectin- and VCAM-1-deficient mice. | Kwee, L., et al. 1995. Ciba Found Symp. 189: 17-28; discussion 28-34, 77-8. PMID: 7587631
- E-selectin is present in proliferating endothelial cells in human hemangiomas. | Kräling, BM., et al. 1996. Am J Pathol. 148: 1181-91. PMID: 8644859
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-Selectin/CD62E/SELE Antibody (UZ6) | sc-59766 | 200 µg/ml | $322.00 | |||
E-Selectin/CD62E/SELE Antibody (UZ6) FITC | sc-59766 FITC | 200 µg/ml | $336.00 | |||
E-Selectin/CD62E/SELE Antibody (UZ6) PE | sc-59766 PE | 200 µg/ml | $349.00 |