Molecular structure of E-64-c, CAS Number: 76684-89-4
E-64-c (CAS 76684-89-4)
See product citations (3)
Alternate Names:
(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane; Loxistatin Acid
Application:
E-64-c is an effective synthetic calpain inhibitor
CAS Number:
76684-89-4
Purity:
≥98%
Molecular Weight:
314.4
Molecular Formula:
C15H26N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
E-64-c is an effective synthetic calpain inhibitor composed from E-64 (sc-201276), which also inhibits cathepsin B, cathepsin H, and cathepsin L (cysteine proteases). The compound has been demonstrated to form a complex with papain by binding via a thioether covalent bond. Studies indicate that E-64-c, also known as Ep-475, is a more potent inhibitor of cathepsins B and L compared to E-64. Mouse lymphosarcoma LS studies show that E-64-c decreases the effects of cyclophosphamide.
E-64-c (CAS 76684-89-4) References
- Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. | Matsumoto, K., et al. 1999. Biopolymers. 51: 99-107. PMID: 10380357
- Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro. | Ohshita, T., et al. 1992. Eur J Biochem. 209: 223-31. PMID: 1382984
- Ester and amide derivatives of E64c as inhibitors of platelet calpains. | Huang, Z., et al. 1992. J Med Chem. 35: 2048-54. PMID: 1597856
- Effect of cysteine protease inhibitor Ep-475 on TNF-alpha-independent cyclophosphamide-induced apoptosis in mouse lymphosarcoma LS cells. | Zhanaeva, SY., et al. 2005. Bull Exp Biol Med. 139: 186-9. PMID: 16027802
- Protease inhibitors prevent the development of human rotavirus-induced diarrhea in suckling mice. | Ebina, T. and Tsukada, K. 1991. Microbiol Immunol. 35: 583-8. PMID: 1723785
- Purification and characterization of cathepsin J from rat liver. | Nikawa, T., et al. 1992. Eur J Biochem. 204: 381-93. PMID: 1740150
- Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. | Yamamoto, D., et al. 1991. J Biol Chem. 266: 14771-7. PMID: 1860874
- High-performance liquid chromatographic determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by pre-column fluorescence derivatization. | Chao, WF., et al. 1990. J Chromatogr. 526: 77-86. PMID: 2341547
- Mode of binding of E-64-c, a potent thiol protease inhibitor, to papain as determined by X-ray crystal analysis of the complex. | Matsumoto, K., et al. 1989. FEBS Lett. 245: 177-80. PMID: 2924921
- In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64. | Tamai, M., et al. 1986. J Pharmacobiodyn. 9: 672-7. PMID: 3023601
- Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium. | Zeman, RJ., et al. 1985. J Biol Chem. 260: 13619-24. PMID: 3932342
- The effect of an in vivo-injected thiol protease inhibitor, E-64-c, on the calcium-induced degeneration of myofilaments. | Ishiura, S., et al. 1981. J Biochem. 90: 1557-60. PMID: 6279581
- Mechanism of postmortem autolysis of skeletal muscle. | Takeichi, S., et al. 1984. Biochem Med. 32: 341-8. PMID: 6393954
- Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c. | Ishiura, S., et al. 1981. J Biochem. 90: 283-5. PMID: 6793567
- L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. | Barrett, AJ., et al. 1982. Biochem J. 201: 189-98. PMID: 7044372
Inhibitor of:
Calpain, cathepsin B, cathepsin H, cathepsin L, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-64-c, 1 mg | sc-201278 | 1 mg | $101.00 | |||
E-64-c, 5 mg | sc-201278A | 5 mg | $392.00 |