(E)-2′-Hydroxychalcone (CAS 888-12-0)

(E)-2′-Hydroxychalcone, a natural phenolic compound, has garnered significant attention in scientific research due to its diverse pharmacological properties and potential applications. Its mechanism of action primarily involves modulation of various cellular signaling pathways and enzyme activities. Researchers have identified (E)-2′-hydroxychalcone as a potent antioxidant, capable of scavenging reactive oxygen species and mitigating oxidative stress-induced cellular damage. Additionally, this compound exhibits anti-inflammatory properties by inhibiting the production of pro-inflammatory mediators and cytokines, thereby attenuating inflammatory responses implicated in various pathological conditions. Moreover, (E)-2′-hydroxychalcone has shown promising anticancer activity through multiple mechanisms, including induction of apoptosis, inhibition of cell proliferation, and suppression of angiogenesis and metastasis. Its ability to target multiple signaling pathways involved in cancer progression makes it a promising candidate for the development of novel anticancer agents. Furthermore, (E)-2′-hydroxychalcone has been investigated for its antimicrobial activity against various bacterial and fungal pathogens, highlighting its potential in combating infectious diseases. Ongoing research endeavors continue to explore the potential of (E)-2′-hydroxychalcone and explain its underlying mechanisms of action, paving the way for the development of novel pharmacological interventions targeting oxidative stress, inflammation, cancer, and infectious diseases.