Dyrk4 Antibody (C-5): sc-393479

Dyrk4 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dyrk4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Dyrk4 antibody (C-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dyrk4, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a crucial role in cellular signaling pathways, particularly in neurogenesis and spermatogenesis regulation. Dyrk4 is predominantly expressed in post-meiotic spermatids, highlighting its importance in male fertility, although studies indicate that Dyrk4 deficiency does not significantly impact male fertility, suggesting functional redundancy within the spermiogenesis pathway. Dyrk4 exists in two isoforms, Dyrk4A and Dyrk4B, which exhibit over 95% sequence homology, underscoring the evolutionary conservation of its function. Post-translational modifications, such as phosphorylation, are essential for Dyrk4 activity and regulation, allowing modulation of various downstream signaling pathways vital for proper cellular function and development.

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Dyrk4 Antibody (C-5) References:

1. Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1.  |  Leypoldt, F., et al. 2001. J Neurochem. 76: 806-14. PMID: 11158252
2. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.  |  Sacher, F., et al. 2007. Mol Cell Endocrinol. 267: 80-8. PMID: 17292540
3. Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.  |  Papadopoulos, C., et al. 2011. J Biol Chem. 286: 5494-505. PMID: 21127067
4. Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.  |  Slepak, TI., et al. 2012. Cytoskeleton (Hoboken). 69: 514-27. PMID: 22359282
5. A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers.  |  Liu, CC., et al. 2021. Clin Cancer Res. 27: 785-798. PMID: 33172895
6. Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.  |  Miyata, Y. and Nishida, E. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 119081. PMID: 34147560
7. Hypomethylation of DYRK4 in peripheral blood is associated with increased lung cancer risk.  |  Qiao, R., et al. 2023. Mol Carcinog. 62: 1745-1754. PMID: 37530470
8. DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation.  |  Zeng, X., et al. 2025. EMBO Rep. 26: 690-719. PMID: 39702801
9. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.  |  Kentrup, H., et al. 1996. J Biol Chem. 271: 3488-95. PMID: 8631952
10. Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.  |  Shindoh, N., et al. 1996. Biochem Biophys Res Commun. 225: 92-9. PMID: 8769099
11. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.  |  Song, WJ., et al. 1996. Genomics. 38: 331-9. PMID: 8975710
12. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.  |  Becker, W., et al. 1998. J Biol Chem. 273: 25893-902. PMID: 9748265

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dyrk4 Antibody (C-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Dyrk4 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dyrk4 Antibody (C-5) Specifications

Alternate Product Name: Dyrk4

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-104

Epitope Target: Dyrk4

Epitope Species: human

Product Reactivity/Detection: Dyrk4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Dyrk4 Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin