Dyrk4 Antibody (B66): sc-130424
- Dyrk4 Antibody (B66) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Dyrk4 of human origin
- recommended for detection of Dyrk4 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dyrk4 Antibody (B66). This work is in progress.
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Dyrk4 Antibody (B66) is a mouse monoclonal IgG2a antibody that detects Dyrk4 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Dyrk4, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a crucial role in various cellular functions, particularly in spermatogenesis and neuronal differentiation. Dyrk4 is predominantly located in post-meiotic spermatids, where Dyrk4 is essential for sperm cell maturation. Dyrk4 presence in this specific cellular compartment underscores Dyrk4′s importance in male fertility, although studies have shown that Dyrk4 deficiency does not adversely affect male reproductive capabilities, suggesting potential redundancy within the spermiogenesis pathway. Dyrk4 exists in two isoforms, Dyrk4A and Dyrk4B, which exhibit over 95% sequence homology, indicating a high degree of conservation and possibly overlapping functions. Dyrk4′s ability to interact with other proteins involved in signaling pathways further highlights Dyrk4′s significance in cellular processes, making anti-Dyrk4 antibody (B66) a valuable tool for researchers studying Dyrk4′s role in human biology.
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Dyrk4 Antibody (B66) References:
- Identification of genes up-regulated by retinoic-acid-induced differentiation of the human neuronal precursor cell line NTERA-2 cl.D1. | Leypoldt, F., et al. 2001. J Neurochem. 76: 806-14. PMID: 11158252
- Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. | Papadopoulos, C., et al. 2011. J Biol Chem. 286: 5494-505. PMID: 21127067
- Sunitinib activates Axl signaling in renal cell cancer. | van der Mijn, JC., et al. 2016. Int J Cancer. 138: 3002-10. PMID: 26815723
- Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone. | Miyata, Y. and Nishida, E. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 119081. PMID: 34147560
- Identification of new ETV6 modulators through a high-throughput functional screening. | Neveu, B., et al. 2022. iScience. 25: 103858. PMID: 35198911
- Roles of dual specificity tyrosine-phosphorylation-regulated kinase 2 in nervous system development and disease. | Santos-Durán, GN. and Barreiro-Iglesias, A. 2022. Front Neurosci. 16: 994256. PMID: 36161154
- Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer? | Liu, CC. and Wang, XS. 2023. Oncotarget. 14: 595-596. PMID: 37306551
- Hypomethylation of DYRK4 in peripheral blood is associated with increased lung cancer risk. | Qiao, R., et al. 2023. Mol Carcinog. 62: 1745-1754. PMID: 37530470
- DnaK promotes autophosphorylation of DYRK1A and its family kinases in Escherichia coli-based cell-free protein expression. | Aoyama, M., et al. 2023. Biochem Biophys Res Commun. 688: 149220. PMID: 37952278
- DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation. | Zeng, X., et al. 2025. EMBO Rep. 26: 690-719. PMID: 39702801
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dyrk4 Antibody (B66) | sc-130424 | 100 µg/ml | $339.00 |