DYNLL1 Antibody (AT13C9): sc-517399
- DYNLL1 Antibody (AT13C9) is a mouse monoclonal IgG2b κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-89 of DYNLL1 of human origin
- recommended for detection of DYNLL1 of human origin by WB, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DYNLL1 Antibody (AT13C9). This work is in progress.
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DYNLL1 Antibody (AT13C9) is a mouse monoclonal IgG2b antibody that detects DYNLL1 in human samples through applications such as western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). DYNLL1, also known as Dynein light chain 1 or DLC8, plays a crucial role in cellular processes by interacting with various proteins, including nitric oxide synthase 1 (NOS1), which is essential for the production of nitric oxide—a signaling molecule involved in numerous physiological functions such as apoptosis, synaptogenesis, and neuronal development. The interaction between DYNLL1 and NOS1 is particularly significant, as DYNLL1 destabilizes the dimerization of NOS1, thereby inhibiting NOS1 activity. This regulatory mechanism highlights DYNLL1′s importance in modulating nitric oxide levels, which can influence critical processes in the nervous system and beyond. DYNLL1 is ubiquitously expressed, with notably high levels in the testis and moderate expression in the brain, underscoring DYNLL1′s potential involvement in reproductive and neurological functions. Anti-DYNLL1 antibody (AT13C9) serves as an invaluable tool for researchers investigating the intricate roles of DYNLL1 in cellular signaling and various biological processes.
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DYNLL1 Antibody (AT13C9) References:
- Dynein-independent functions of DYNLL1/LC8: redox state sensing and transcriptional control. | King, SM. 2008. Sci Signal. 1: pe51. PMID: 19036713
- The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma. | Wong, DM., et al. 2016. Cell Rep. 14: 1488-1499. PMID: 26832406
- Dynein light chain DYNLL1 subunit facilitates porcine circovirus type 2 intracellular transports along microtubules. | Theerawatanasirikul, S., et al. 2017. Arch Virol. 162: 677-686. PMID: 27858289
- Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia. | King, A., et al. 2019. Hum Mol Genet. 28: 2573-2588. PMID: 31009951
- An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution. | Zalmas, LP., et al. 2019. Ann Transl Med. 7: S93. PMID: 31576301
- The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species. | Yuan, J., et al. 2020. Infect Immun. 88: PMID: 32041786
- In silico analysis of DYNLL1 expression in ovarian cancer chemoresistance. | Berkel, C. and Cacan, E. 2020. Cell Biol Int. 44: 1598-1605. PMID: 32208526
- DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma. | Li, Q., et al. 2022. J Transl Med. 20: 245. PMID: 35619131
- Dynll1-PI31 Interaction Enhances Proteolysis via the Proteasome, Representing a Novel Therapeutic Target for INF2-Related FSGS. | Williquett, J., et al. 2024. Kidney360. 6: 38-48. PMID: 39621430
- DYNLL1 ubiquitinated and degraded by E3 ligase PRKN regulates cell cycle arrest and apoptosis in lung adenocarcinoma cells. | Tang, H. and Wei, C. 2024. Discov Oncol. 15: 806. PMID: 39692845
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DYNLL1 Antibody (AT13C9) | sc-517399 | 100 µg/ml | $322.00 |