Dynein IC1/2, cytosolic Antibody (C-2): sc-136971

Dynein IC1/2, cytosolic Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects Dynein in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Dynein IC1/2 antibody (C-2) targets the cytoplasmic Dynein complex, which is essential for various cellular processes, including organelle transport and centrosome assembly, thereby playing a critical role in maintaining cellular organization and function. Dynein IC1/2 (C-2) monoclonal antibody recognizes a structure consisting of approximately 12 subunits, including two heavy chains that provide motor function, two intermediate chains that anchor Dynein to cargo, and several light chains that contribute to stability and regulation. The carboxy terminus of Dynein is crucial for microtubule-dependent motility and is highly conserved across species, while amino terminal regions exhibit more variability, allowing for specific interactions with various regulatory proteins. Dynein IC1/2 (C-2) antibody helps researchers study interactions with several proteins, including dynactin, LIS1, and NudEL (NudE-like), which are vital for proper functioning in cellular transport mechanisms. The ability of Dynein to convert ATP′s chemical energy into mechanical movement underscores its significance in cellular dynamics, making Dynein IC1/2 (C-2) monoclonal antibody an invaluable tool for studying cellular transport and motility.

The preferred Dynein IC1/2, cytosolic antibody is Dynein IC1/2, cytosolic Antibody (74-1): sc-13524.