Molecular structure of Dynasore monohydrate, CAS Number: 304448-55-3 (anhydrous)
Dynasore monohydrate (CAS 304448-55-3 (anhydrous))
See product citations (2)
Alternate Names:
3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Application:
Dynasore monohydrate is a reversible noncompetitive dynamin 1 and 2 GTPase activity inhibitor
CAS Number:
304448-55-3 (anhydrous)
Molecular Weight:
340.33
Molecular Formula:
C18H14N2O4•H2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Dynasore monohydrate is a cell-permeable, reversible noncompetitive dynamin 1 and 2 GTPase activity inhibitor, where it also inhibits mitochondrial Drp1. Dynasore blocks dynamin-dependent endocytosis and scission of endocytic vesicles. it is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore monohydrate (CAS 304448-55-3 (anhydrous)) References
- Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. | Poirier, S., et al. 2009. J Biol Chem. 284: 28856-64. PMID: 19635789
- The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells. | Beauvillain, C., et al. 2010. J Hepatol. 52: 644-51. PMID: 20338659
- A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells. | Gold, S., et al. 2010. PLoS One. 5: e11360. PMID: 20613878
- Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells. | Rosa, JM., et al. 2010. Pflugers Arch. 460: 901-14. PMID: 20640579
- Antigen-presenting cell marker expression and phagocytotic activity in periodontal ligament cells. | Konermann, A., et al. 2012. J Oral Pathol Med. 41: 340-7. PMID: 21950503
- Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion. | de la Vega, M., et al. 2011. Retrovirology. 8: 99. PMID: 22145853
- Integrin endosomal signalling suppresses anoikis. | Alanko, J., et al. 2015. Nat Cell Biol. 17: 1412-21. PMID: 26436690
- Biological Atomic Force Microscopy for Imaging Gold-Labeled Liposomes on Human Coronary Artery Endothelial Cells. | Zaske, AM., et al. 2013. J Pharm (Cairo). 2013: 875906. PMID: 26555999
- Aquaporin-4 Cell-Surface Expression and Turnover Are Regulated by Dystroglycan, Dynamin, and the Extracellular Matrix in Astrocytes. | Tham, DK., et al. 2016. PLoS One. 11: e0165439. PMID: 27788222
- Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment. | Khan, TF., et al. 2018. Int J Biochem Cell Biol. 101: 54-63. PMID: 29800726
- Helicobacter pylori Outer Membrane Vesicle Size Determines Their Mechanisms of Host Cell Entry and Protein Content. | Turner, L., et al. 2018. Front Immunol. 9: 1466. PMID: 30013553
- Dextran sulphate inhibits an association of prions with plasma membrane at the early phase of infection. | Fuse, T., et al. 2021. Neurosci Res. 171: 34-40. PMID: 33476681
- Dynamin-2 controls actin remodeling for efficient complement receptor 3-mediated phagocytosis. | Mularski, A., et al. 2023. Biol Cell. e202300001. PMID: 37095727
Inhibitor of:
DRP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dynasore monohydrate, 5 mg | sc-214953 | 5 mg | $79.00 | |||
Dynasore monohydrate, 25 mg | sc-214953A | 25 mg | $315.00 |