Date published: 2026-4-5

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Dynamin Inhibitor I, Dynasore (CAS 304448-55-3)

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Alternate Names:
Dynamin Inhibitor I, Dynasore is known as a Dynamin I and Dynamin II inhibitor.
Application:
Dynamin Inhibitor I, Dynasore is a non-competitive, cell-permeable semicarbazone compound inhibitor of Dynamin I and Dynamin II.
CAS Number:
304448-55-3
Purity:
≥98%
Molecular Weight:
322.31
Molecular Formula:
C18H14N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dynamin Inhibitor I, Dynasore is a non-competitive, cell-permeable semicarbazone compound inhibitor of Dynamin I and Dynamin II. Members of the Dynamin family, including Dynamin I, Dynamin II and Dynamin III, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Dynamin Inhibitor I, Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by blocking coated vesicle formation. Dynamin Inhibitor I, Dynasore is an inhibitor of DRP1.


Dynamin Inhibitor I, Dynasore (CAS 304448-55-3) References

  1. Dynasore, a cell-permeable inhibitor of dynamin.  |  Macia, E., et al. 2006. Dev Cell. 10: 839-50. PMID: 16740485
  2. Discovery of a new 'dynasore'.  |  Thompson, HM. and McNiven, MA. 2006. Nat Chem Biol. 2: 355-6. PMID: 16783339
  3. Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation.  |  Nankoe, SR. and Sever, S. 2006. Trends Cell Biol. 16: 607-9. PMID: 17064900
  4. Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis.  |  Newton, AJ., et al. 2006. Proc Natl Acad Sci U S A. 103: 17955-60. PMID: 17093049
  5. HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore.  |  Abban, CY., et al. 2008. Am J Ther. 15: 304-11. PMID: 18645330
  6. Dynasore inhibits removal of wild-type and DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane.  |  Young, A., et al. 2009. Biochem J. 421: 377-85. PMID: 19442237
  7. Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.  |  Yamada, H., et al. 2009. Biochem Biophys Res Commun. 390: 1142-8. PMID: 19857461
  8. Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages.  |  Barrias, ES., et al. 2010. PLoS One. 5: e7764. PMID: 20098746
  9. Dynasore, an inhibitor of dynamin, increases the probability of transmitter release.  |  Douthitt, HL., et al. 2011. Neuroscience. 172: 187-95. PMID: 21056636
  10. The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages.  |  Girard, E., et al. 2011. PLoS One. 6: e29042. PMID: 22205993
  11. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats.  |  Li, G., et al. 2017. Mol Neurobiol. 54: 7471-7482. PMID: 27822712
  12. Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.  |  Zhong, B., et al. 2019. Cell Death Dis. 10: 687. PMID: 31534119
  13. Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration.  |  Clemente, LP., et al. 2020. Cells. 9: PMID: 33050207
  14. Targeting the blood-brain barrier disruption in hypertension by ALK5/TGF-Β type I receptor inhibitor SB-431542 and dynamin inhibitor dynasore.  |  Atis, M., et al. 2022. Brain Res. 1794: 148071. PMID: 36058283

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dynamin Inhibitor I, Dynasore, 10 mg

sc-202592
10 mg
$89.00