DYDC2 Antibody (9H8): sc-134323
- DYDC2 Antibody (9H8) is a mouse monoclonal IgG2a κ DYDC2 antibody provided at 100 µg/ml
- raised against recombinant DYDC2 protein of human origin
- recommended for detection of DYDC2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DYDC2 Antibody (9H8). This work is in progress.
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DYDC2 Antibody (9H8) is a mouse monoclonal IgG2a kappa light chain antibody that detects DYDC2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DYDC2 antibody (9H8) is available as the non-conjugated isotype antibody. DYDC2 protein, also known as DPY30 domain-containing protein 2, plays a crucial role in regulating gene expression and chromatin modifications, particularly through involvement in histone methylation. DYDC2 is part of the DPY-30 family, which is conserved across species from yeast to humans and is essential for dosage compensation of sex chromosomes, a process ensuring equal expression of genes from sex chromosomes in both males and females. DYDC2, comprising 177 amino acids, includes a short motif similar to the dimerization motif found in the regulatory subunit of protein kinase A, allowing formation of a four-helix bundle during dimerization. This structural feature influences DYDC2′s ability to interact with other regulatory proteins, thereby modulating gene expression. Notably, knockdown of DYDC2 mRNA results in male sterility due to impaired sperm motility, highlighting DYDC2′s importance in reproductive biology.
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DYDC2 Antibody (9H8) References:
- The Caenorhabditis elegans dosage compensation machinery is recruited to X chromosome DNA attached to an autosome. | Lieb, JD., et al. 2000. Genetics. 156: 1603-21. PMID: 11102361
- Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex. | Dong, X., et al. 2005. Biochim Biophys Acta. 1753: 257-62. PMID: 16260194
- Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. | Kuhl, A., et al. 2008. Eur J Hum Genet. 16: 367-73. PMID: 18197198
- Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. | Vardanyan, A., et al. 2008. BMC Dev Biol. 8: 68. PMID: 18588663
- Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex. | Wang, X., et al. 2009. J Mol Biol. 390: 530-7. PMID: 19481096
- Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. | Li, S., et al. 2009. Eur J Cell Biol. 88: 509-20. PMID: 19545932
- On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. | Patel, A., et al. 2009. J Biol Chem. 284: 24242-56. PMID: 19556245
- DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation. | Hsu, DR., et al. 1995. Development. 121: 3323-34. PMID: 7588066
- The dpy-30 gene encodes an essential component of the Caenorhabditis elegans dosage compensation machinery. | Hsu, DR. and Meyer, BJ. 1994. Genetics. 137: 999-1018. PMID: 7982580
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DYDC2 Antibody (9H8) | sc-134323 | 100 µg/ml | $333.00 |