Dutasteride-13C6
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Dutasteride-13C6 is a compound that inhibits the enzyme 5-alpha reductase, which is responsible for the conversion of testosterone to dihydrotestosterone (DHT). By blocking this enzyme, Dutasteride-13C6 reduces the levels of DHT.This reduction in DHT levels can lead to a decrease in the size of the prostate gland in animal models. Dutasteride-13C6 may inhibit the growth of androgen-dependent and androgen-independent prostate cancer cells in preclinical studies. At the molecular level, Dutasteride-13C6 binds to the active site of 5-alpha reductase, preventing the conversion of testosterone to DHT. This mechanism of action may be a useful for studying the role of DHT in prostate growth and cancer progression in experimental models.
Dutasteride-13C6 References
- Reliable and sensitive determination of dutasteride in human plasma by liquid chromatography-tandem mass spectrometry. | Contractor, P., et al. 2013. Biomed Chromatogr. 27: 1168-76. PMID: 23636821
- Inhibition of 5α-reductase alters pregnane metabolism in the late pregnant mare. | Wynn, MAA., et al. 2018. Reproduction. 155: 251-258. PMID: 29339451
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dutasteride-13C6, 1 mg | sc-218282 | 1 mg | $584.00 |