DUSP27 Antibody (F-12): sc-515513

DUSP27 Antibody (F-12) is a mouse monoclonal IgM antibody that detects DUSP27 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DUSP27 antibody (F-12) is available as the non-conjugated form. DUSP27, also known as dual specificity phosphatase 27 or DUPD1, is a 220 amino acid cytoplasmic protein that plays a crucial role in regulating cellular signaling pathways by dephosphorylating both phosphothreonine and phosphotyrosine residues within mitogen-activated protein (MAP) kinases. This regulation helps control various cellular processes, including growth, differentiation, and stress responses. DUSP27 expression is induced by several growth factors and cellular stresses, which allows DUSP27 to negatively regulate members of the MAP kinase superfamily, such as MAPK/ERK, SAPK/JNK, and p38, thereby maintaining cellular homeostasis. DUSP27 is predominantly expressed in skeletal muscle, liver, and adipose tissue, suggesting involvement in energy metabolism and metabolic regulation. The gene encoding DUSP27, referred to as DUPD1, is located on human chromosome 10, which contains over 1,200 genes and represents nearly 4.5% of the human genome, highlighting DUSP27′s importance in various physiological processes.

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DUSP27 Antibody (F-12) References:

1. A growing family of dual specificity phosphatases with low molecular masses.  |  Aoki, N., et al. 2001. J Biochem. 130: 133-40. PMID: 11432789
2. Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14.  |  Nonneman, D. and Rohrer, GA. 2004. Anim Genet. 35: 338-43. PMID: 15265077
3. Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes.  |  Salojin, K. and Oravecz, T. 2007. J Leukoc Biol. 81: 860-9. PMID: 17289800
4. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.  |  Jeffrey, KL., et al. 2007. Nat Rev Drug Discov. 6: 391-403. PMID: 17473844
5. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase.  |  Friedberg, I., et al. 2007. FEBS Lett. 581: 2527-33. PMID: 17498703
6. Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress.  |  Teng, CH., et al. 2007. J Biol Chem. 282: 28395-28407. PMID: 17681939
7. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines.  |  Kwak, SP. and Dixon, JE. 1995. J Biol Chem. 270: 1156-60. PMID: 7836374
8. A novel dual specificity phosphatase induced by serum stimulation and heat shock.  |  Ishibashi, T., et al. 1994. J Biol Chem. 269: 29897-902. PMID: 7961985

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DUSP27 Antibody (F-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DUSP27 Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DUSP27 Antibody (F-12) Specifications

Alternate Product Name: DUSP27

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 60-86

Epitope Target: DUSP27

Epitope Species: human

Product Reactivity/Detection: DUSP27

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DUSP27 Antibody (F-12): P: Blocking Peptide