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Duramycin (CAS 1391-36-2)

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Alternate Names:
Duramycin is also known as Lancovutide.
Application:
Duramycin is a chloride secretion enhancer in cardial, pancreatic and airway epithelial voltage-gated ion channels.
CAS Number:
1391-36-2
Purity:
≥90%
Molecular Weight:
2013.27
Molecular Formula:
C89H125N23O25S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Duramycin is a polypeptide antibiotic with a defined 3-dimensional binding structure. It is the smallest known polypeptide, with only 19 amino acids. Duramycin enhances chloride secretion in airway epithelium. It is used in studies of cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. Duramycin is also known as Lancovutide and Leucopeptin.


Duramycin (CAS 1391-36-2) References

  1. Ozonation of oxytetracycline and toxicological assessment of its oxidation by-products.  |  Li, K., et al. 2008. Chemosphere. 72: 473-8. PMID: 18355893
  2. Toxic interaction mechanism between oxytetracycline and bovine hemoglobin.  |  Chi, Z., et al. 2010. J Hazard Mater. 180: 741-7. PMID: 20494513
  3. Duramycin enhances chloride secretion in airway epithelium.  |  Cloutier, MM., et al. 1990. Am J Physiol. 259: C450-4. PMID: 2169195
  4. Antibacterial activity of oxytetracycline photoproducts in marine aquaculture's water.  |  Leal, JF., et al. 2017. Environ Pollut. 220: 644-649. PMID: 27769773
  5. Expanding the application scope of on-farm biopurification systems: Effect and removal of oxytetracycline in a biomixture.  |  Jiménez-Gamboa, D., et al. 2018. J Hazard Mater. 342: 553-560. PMID: 28886567
  6. Performance of bimetallic nanoscale zero-valent iron particles for removal of oxytetracycline.  |  Wu, Y., et al. 2018. J Environ Sci (China). 69: 173-182. PMID: 29941253
  7. Evaluation of antibiotic oxytetracycline removal in water using a gas phase dielectric barrier discharge plasma.  |  Tang, S., et al. 2018. J Environ Manage. 226: 22-29. PMID: 30103200
  8. Polycaprolactone nanofibers loaded oxytetracycline hydrochloride and zinc oxide for treatment of periodontal disease.  |  Dias, AM., et al. 2019. Mater Sci Eng C Mater Biol Appl. 103: 109798. PMID: 31349501
  9. Simultaneous Determination of Streptomycin and Oxytetracycline using a Oracet-Blue/Silver-Nanoparticle/Graphene-Oxide/Modified Screen-Printed Electrode.  |  Akbarzadeh, S., et al. 2020. Biosensors (Basel). 10: PMID: 32168735
  10. Evaluating approved and alternative treatments against an oxytetracycline-resistant bacterium responsible for European foulbrood disease in honey bees.  |  Masood, F., et al. 2022. Sci Rep. 12: 5906. PMID: 35393467
  11. A study of the effect of reactive oxygen species induced by violet and blue light from oxytetracycline on the deactivation of Escherichia coli.  |  Cheng, CW., et al. 2022. Photodiagnosis Photodyn Ther. 39: 102917. PMID: 35597444
  12. A Preliminary Study on the Concentration of Oxytetracycline and 4-Epi-Oxytetracycline in Sow Milk.  |  Cybulski, P., et al. 2022. Molecules. 27: PMID: 35630734
  13. Inhibitory effect of duramycin on partial reactions catalyzed by (Na+,K+)-adenosinetriphosphatase from dog kidney.  |  Nakamura, S. and Racker, E. 1984. Biochemistry. 23: 385-9. PMID: 6320868
  14. Bioavailability of oxytetracycline dihydrate tablets in dogs.  |  Cooke, RG., et al. 1981. J Vet Pharmacol Ther. 4: 11-3. PMID: 7349318
  15. Oxytetracycline residues in pigs fed experimentally.  |  Jones, CR., et al. 1977. Can Vet J. 18: 150-3. PMID: 880538

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Duramycin, 10 mg

sc-239840
10 mg
$500.00

What is Endotoxin/ LPS content in your duramycin product? Can it be used to work with human immune cells?

Asked by: Evelien
Thank you for your question. Endotoxin/ LPS content is not determined for this compound.
Answered by: Tech Support Europe
Date published: 2021-02-09

In which type of solvents duramycin will not dissolve. Information needed for selective purification of duramycin from conjugates used such as DOTAGA

Asked by: Gurvinder
We have limited solubility information on this chemical. Duramycin is soluble in 0.1 M HCl at 10 mg/mL.
Answered by: Technical Support
Date published: 2019-01-06

What is the diluent used for duramycin? 

Asked by: YOKEFUN
Thank you for your question. We offer Duramycin (CAS 1391-36-2): sc-239840 as a solid and not in a solution. This is soluble in 0.1 M HCl at 10 mg/mL.
Answered by: Technical Support
Date published: 2018-01-30
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Rated 5 out of 5 by from Hou S; et alHou S; et al. (PubMed ID: 26224023) determined that Duramycin bound to the c-terminus of GFP protein still specifically binds to Phosphatidylethanolamine, but has less toxcity than that of native Duramycin. -SCBT Publication Review
Date published: 2015-03-19
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Duramycin | CAS 1391-36-2 is rated 5.0 out of 5 by 1.
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