Molecular structure of Duloxetine, CAS Number: 116539-59-4
Duloxetine (CAS 116539-59-4)
See product citations (3)
Alternate Names:
(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
Application:
Duloxetine is an inhibitor of ST and SLC6A2
CAS Number:
116539-59-4
Purity:
≥99%
Molecular Weight:
297.42
Molecular Formula:
C18H19NOS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Duloxetine is an ST and SLC6A2 inhibitor (serotonin-norepinephrine reuptake inhibitor/SNRI). Duloxetine exerts its effects by increasing the levels of serotonin and norepinephrine in the brain. It accomplishes this by modulating the activity of specific enzymes, such as monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), which are responsible for the breakdown of serotonin and norepinephrine. In vitro investigations employing cell cultures and tissue slices have demonstrated the antidepressant-like properties of duloxetine, along with anxiolytic and antinociceptive effects. These studies have also employed duloxetine to explore the impact of serotonin and norepinephrine on cellular and tissue physiology.
Duloxetine (CAS 116539-59-4) References
- Duloxetine plasma level and antidepressant response. | De Donatis, D., et al. 2019. Prog Neuropsychopharmacol Biol Psychiatry. 92: 127-132. PMID: 30611837
- Serotonin and Norepinephrine Reuptake Inhibitors. | Shelton, RC. 2019. Handb Exp Pharmacol. 250: 145-180. PMID: 30838456
- Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. | Osani, MC. and Bannuru, RR. 2019. Korean J Intern Med. 34: 966-973. PMID: 30871298
- Duloxetine for pain in fibromyalgia in adults: a systematic review and a meta-analysis. | Lian, YN., et al. 2020. Int J Neurosci. 130: 71-82. PMID: 31487217
- Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study. | Huybrechts, KF., et al. 2020. BMJ. 368: m237. PMID: 32075794
- Duloxetine Attenuates Paclitaxel-Induced Peripheral Nerve Injury by Inhibiting p53-Related Pathways. | Lu, Y., et al. 2020. J Pharmacol Exp Ther. 373: 453-462. PMID: 32238452
- Duloxetine strengthens osteoblast activation by prostaglandin E1: Upregulation of p38 MAP kinase. | Tachi, J., et al. 2020. Prostaglandins Other Lipid Mediat. 151: 106481. PMID: 33002595
- Bioaccumulation of therapeutic drugs by human gut bacteria. | Klünemann, M., et al. 2021. Nature. 597: 533-538. PMID: 34497420
- Duloxetine-induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Super-elderly Patient. | Hamada, T., et al. 2022. Intern Med. 61: 1099-1103. PMID: 34511565
- Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia. | Nakamura, M., et al. 2022. Hum Psychopharmacol. 37: e2818. PMID: 34541697
- The Antidepressant Duloxetine Inhibits Platelet Function and Protects against Thrombosis. | Lozano, PA., et al. 2022. Int J Mol Sci. 23: PMID: 35269729
- Inhibitory effects of fluoxetine and duloxetine on the pharmacokinetics of metoprolol in vivo and in vitro. | Xu, T., et al. 2022. Fundam Clin Pharmacol. 36: 1057-1065. PMID: 35510497
- Efficacy of pelvic floor muscle exercise or therapy with or without duloxetine: a systematic review and network Meta-analysis. | Park, JJ., et al. 2022. Aging Male. 25: 145-155. PMID: 35535703
- Enantioseparation of N-methyl duloxetine, duloxetine, and fluoxetine by countercurrent chromatography using anionic β-cyclodextrin as chiral selector. | Sun, W., et al. 2022. J Sep Sci. 45: 3022-3030. PMID: 35598113
- Duloxetine and osteoarthritis, a herd of elephants in the room: comment on the article by van den Driest et al. | Braillon, A. 2022. Arthritis Rheumatol. 74: 1859. PMID: 35792040
Inhibitor of:
SLC6A2, and ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Duloxetine, 10 mg | sc-279011 | 10 mg | $126.00 |