DU 145 Cell Lysate: sc-2268

DU 145 cell lysate is derived from the DU 145 cell line, a human prostate adenocarcinoma model commonly used in cancer research to study the biology and treatment responses of prostate cancer cells. This lysate is particularly valuable for analyzing the effects of genetic and chemical manipulations on cell proliferation, apoptosis, androgen receptor signaling, and other pathways relevant to prostate cancer progression. Researchers utilize DU 145 lysate to explore mechanisms of resistance to conventional treatments like hormone therapy, focusing on pathways such as PI3K/Akt and MAPK, which are critical for cell survival and proliferation. Additionally, the lysate provides insights into the role of p53 mutations and PTEN deletions, which are prevalent in DU 145 cells and contribute to the aggressive behavior of prostate cancer. Studies using this lysate also examine the cellular response to new pharmacological inhibitors and the modulation of gene expression involved in cell cycle regulation and metastasis. This research aids in understanding the molecular underpinnings of prostate cancer, contributing to the development of more effective research tools and methods.

DU 145 Cell Lysate References:

1. The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin.  |  McGowen, R., et al. 2000. Cancer Res. 60: 4771-8. PMID: 10987285
2. Increased stability of macrophage migration inhibitory factor (MIF) in DU-145 prostate cancer cells.  |  Meyer-Siegler, K. 2000. J Interferon Cytokine Res. 20: 769-78. PMID: 11032396
3. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.  |  Jiang, C., et al. 2001. Cancer Res. 61: 3062-70. PMID: 11306488
4. Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli.  |  Bastola, DR., et al. 2002. Mol Cell Biochem. 236: 75-81. PMID: 12190124
5. Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.  |  Agarwal, C., et al. 2007. Carcinogenesis. 28: 1463-70. PMID: 17341659
6. Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2.  |  Mize, GJ., et al. 2008. Mol Cancer Res. 6: 1043-51. PMID: 18567807
7. GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity.  |  Fiorentini, C., et al. 2014. Exp Cell Res. 323: 100-111. PMID: 24589892
8. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells.  |  Don-Doncow, N., et al. 2014. J Biol Chem. 289: 15969-78. PMID: 24755219
9. Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells.  |  Kim, YH., et al. 2018. Bioorg Med Chem Lett. 28: 2566-2572. PMID: 29807795
10. High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line.  |  Hacioglu, C., et al. 2020. Biol Trace Elem Res. 193: 400-409. PMID: 31066018
11. The effects of L-NAME on DU145 human prostate cancer cell line: A cytotoxicity-based study.  |  Kacar, S., et al. 2020. Hum Exp Toxicol. 39: 182-193. PMID: 31610702
12. Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells.  |  Lee, YJ., et al. 2020. Biochem Pharmacol. 175: 113920. PMID: 32201212
13. Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145.  |  Peng, D., et al. 1996. Cancer Res. 56: 3666-9. PMID: 8706005