Molecular structure of DSP-4 hydrochloride, CAS Number: 40616-75-9
DSP-4 hydrochloride (CAS 40616-75-9)
See product citations (3)
Alternate Names:
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
Application:
DSP-4 hydrochloride is An adrenergic neuron blocking agent with inhibitory effects on the uptake of noradrenaline
CAS Number:
40616-75-9
Purity:
≥95%
Molecular Weight:
313.06
Molecular Formula:
C11H15BrClN•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DSP-4 hydrochloride is a highly polar organo-halogen compound that falls under the category of nitrogen-containing heterocycles. The precise mechanism of action for DSP-4 hydrochloride remains partially elucidated. However, it is believed to engage with a range of cellular targets, including enzymes and receptors. Through binding to these targets, it is thought to modulate their activity. In in vitro studies in brain slices DSP-4 hydrochloride acted as an adrenergic neuron blocking agent with long-lasting inhibitory effect on the uptake of noradrenaline (norepinephrine).
DSP-4 hydrochloride (CAS 40616-75-9) References
- Noradrenergic mechanisms in the central amygdalar nucleus and gastric stress ulcer formation in rats. | Ray, A., et al. 1990. Neurosci Lett. 110: 331-6. PMID: 2325904
- Involvement of the paraventricular (PVN) and arcuate (ARC) nuclei of the hypothalamus in the central noradrenergic regulation of liver cytochrome P450. | Bromek, E., et al. 2013. Biochem Pharmacol. 86: 1614-20. PMID: 24051135
- Stimulation of postsynapse adrenergic α2A receptor improves attention/cognition performance in an animal model of attention deficit hyperactivity disorder. | Kawaura, K., et al. 2014. Behav Brain Res. 270: 349-56. PMID: 24882610
- Effect of DSP-4, a noradrenergic neurotoxin, on sleep and wakefulness and sensitivity to drugs acting on adrenergic receptors in the rat. | Monti, JM., et al. 1988. Sleep. 11: 370-7. PMID: 2849796
- Involvement of central noradrenergic pathways in the control of intestinal motility in rats. | Fargeas, MJ., et al. 1988. Neurosci Lett. 90: 297-301. PMID: 3419640
- A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation. | Wang, J., et al. 2021. Front Mol Neurosci. 14: 752838. PMID: 34916906
- Suppressant effect of REM sleep deprivation on neophobia in normal rats and in rats with selective DSP-4 induced damage of locus coeruleus neurons. | Mogilnicka, E., et al. 1985. Pharmacol Biochem Behav. 23: 93-7. PMID: 4034624
- Cyclizing compounds. I. Tertiary N-(2-bromobenzyl)-N-haloalkylamines with adrenergic blocking action. | Ross, SB., et al. 1973. Acta Pharm Suec. 10: 29-42. PMID: 4145284
- Effect of DSP-4, pCPA, and haloperidol on hippocampal electrical activity and behavior in rabbits. | Fontani, G. and Farabollini, F. 1984. Behav Neural Biol. 40: 213-26. PMID: 6233963
- DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)--a useful denervation tool for central and peripheral noradrenaline neurons. | Jonsson, G., et al. 1981. Eur J Pharmacol. 72: 173-88. PMID: 6265244
- Functional supersensitivity to adrenergic agonists in the rat after DSP-4, a selective noradrenergic neurotoxin. | Dooley, DJ., et al. 1983. Psychopharmacology (Berl). 81: 1-5. PMID: 6415724
- Norepinephrine loss exacerbates methamphetamine-induced striatal dopamine depletion in mice. | Fornai, F., et al. 1995. Eur J Pharmacol. 283: 99-102. PMID: 7498327
- Region- and neurotransmitter-dependent species and strain differences in DSP-4-induced monoamine depletion in rodents. | Fornai, F., et al. 1996. Neurodegeneration. 5: 241-9. PMID: 8910902
- Effects of noradrenergic lesions on MPTP/MPP+ kinetics and MPTP-induced nigrostriatal dopamine depletions. | Fornai, F., et al. 1997. J Pharmacol Exp Ther. 283: 100-7. PMID: 9336313
- Effects of pretreatment with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on methamphetamine pharmacokinetics and striatal dopamine losses. | Fornai, F., et al. 1999. J Neurochem. 72: 777-84. PMID: 9930753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DSP-4 hydrochloride, 5 mg | sc-202145 | 5 mg | $51.00 | |||
DSP-4 hydrochloride, 25 mg | sc-202145A | 25 mg | $204.00 |