DSC2/3 Antibody (3G130): sc-70994

DSC2/3 Antibody (3G130) is a mouse monoclonal IgG1 antibody that detects DSC2/3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). DSC2/3 is a crucial member of the desmosomal cadherin family, playing a significant role in cell adhesion and maintaining the structural integrity of tissues, particularly in the epidermis. DSC2/3 (3G130) antibody is predominantly localized to specialized adhesion junctions, facilitating strong intercellular connections that are essential for tissue resilience against mechanical stress. DSC2/3 functions not only in structural roles but also in signaling pathways that regulate cell behavior and tissue homeostasis. Notably, DSC2 interacts homophilically with itself and heterophilically with desmoglein 2, which enhances the adhesive properties of desmosomes and contributes to the overall stability of epithelial layers. DSC2/3 presence in various stratified epithelia, including the cervix, tongue, and esophagus, underscores DSC2/3′s vital function in maintaining the integrity of these tissues under physiological and pathological conditions. With robust reactivity and versatility in multiple applications, anti-DSC2/3 antibody (3G130) serves as an invaluable tool for researchers studying cell adhesion mechanisms and desmosomal dynamics.

The preferred DSC2/3 antibody is DSC2/3 Antibody (7G6): sc-53485.