Molecular structure of DS2, CAS Number: 374084-31-8
DS2 (CAS 374084-31-8)
Application:
DS2 is a positive allosteric modulator of δ-subunit containing GABAA receptors
CAS Number:
374084-31-8
Molecular Weight:
353.83
Molecular Formula:
C18H12CIN3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DS2 a positive allosteric modulator of delta-subunit containing GABAA receptors (EC50 = 142 nM for alpha4beta3delta receptors). May display no effects on GABA responses mediated by alpha4beta3gamma2 and alpha1beta3gamma2 receptors. Experimental studies conducted in laboratory applications have demonstrated that DS2 exhibits antioxidant properties, offering protection against oxidative stress. Additionally, it may possess anti-apoptotic characteristics, helping to inhibit programmed cell death. Moreover, DS2 displays cytoprotective effects, safeguarding cells from various detrimental factors.
DS2 (CAS 374084-31-8) References
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- Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and Δ subunits have opposite effects on surface expression. | Bracamontes, JR., et al. 2014. Mol Pharmacol. 86: 20-7. PMID: 24723490
- Synaptic GABAA receptor clustering without the γ2 subunit. | Kerti-Szigeti, K., et al. 2014. J Neurosci. 34: 10219-33. PMID: 25080584
- In vitro gamma oscillations following partial and complete ablation of Δ subunit-containing GABAA receptors from parvalbumin interneurons. | Ferando, I. and Mody, I. 2015. Neuropharmacology. 88: 91-8. PMID: 25261782
- Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING. | Zhong, W., et al. 2015. J Biol Chem. 290: 18400-11. PMID: 25979331
- Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation. | Tonsfeldt, KJ., et al. 2016. J Neurosci. 36: 1669-81. PMID: 26843648
- Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic ΔGABA(A) Receptors. | Carver, CM. and Reddy, DS. 2016. J Pharmacol Exp Ther. 357: 188-204. PMID: 26857959
- Toward Understanding Functional Properties and Subunit Arrangement of α4β2Δ γ-Aminobutyric Acid, Type A (GABAA) Receptors. | Wongsamitkul, N., et al. 2016. J Biol Chem. 291: 18474-83. PMID: 27382064
- Neurosteroid-sensitive Δ-GABAA receptors: A role in epileptogenesis? | Joshi, S., et al. 2017. Epilepsia. 58: 494-504. PMID: 28452419
- The Delta-Subunit Selective GABA A Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism. | Neumann, S., et al. 2019. Front Neurosci. 13: 1133. PMID: 31736685
- Efficient expression of concatenated α1β2Δ and α1β3Δ GABAA receptors, their pharmacology and stoichiometry. | Liao, VWY., et al. 2021. Br J Pharmacol. 178: 1556-1573. PMID: 33491192
- Extrasynaptic Δ-subunit containing GABAA receptors. | Arslan, A. 2021. J Integr Neurosci. 20: 173-184. PMID: 33834705
- Structural Determinants for the Mode of Action of Imidazopyridine DS2 at Δ-Containing γ-Aminobutyric Acid Type A Receptors. | Rostrup, F., et al. 2021. J Med Chem. 64: 4730-4743. PMID: 33847501
- Molecular Determinants Underlying Delta Selective Compound 2 Activity at Δ-Containing GABAA Receptors. | Falk-Petersen, CB., et al. 2021. Mol Pharmacol. 100: 46-56. PMID: 33990405
- The Influence of AA29504 on GABAA Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity. | Sikstus, S., et al. 2022. Neurochem Res. 47: 667-678. PMID: 34727270
Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DS2, 10 mg | sc-294421 | 10 mg | $520.00 | |||
DS2, 25 mg | sc-294421A | 25 mg | $1144.00 |