Date published: 2025-10-8

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Drofenine hydrochloride (CAS 548-66-3)

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Alternate Names:
Hexahydroadiphenine
CAS Number:
548-66-3
Molecular Weight:
353.93
Molecular Formula:
C20H31NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Drofenine hydrochloride interacts with cellular components by binding to specific receptors on the surface of cells. Drofenine hydrochloride interferes with the transmission of signals within the nervous system, leading to a reduction in the perception of pain. Drofenine hydrochloride modulates the release of certain neurotransmitters, such as acetylcholine, which further contributes to its analgesic effects. Drofenine hydrochloride affects the function of ion channels in the cell membrane, leading to changes in the membrane potential and the transmission of electrical signals.


Drofenine hydrochloride (CAS 548-66-3) References

  1. Rapid determination of propyphenazone in plasma by high-performance liquid chromatography.  |  Rouan, MC., et al. 1992. J Chromatogr. 577: 387-90. PMID: 1400772
  2. Inhibition of Listeria monocytogenes infection by neurological drugs.  |  Lieberman, LA. and Higgins, DE. 2010. Int J Antimicrob Agents. 35: 292-6. PMID: 20031379
  3. Large-Scale Phenotype-Based Antiepileptic Drug Screening in a Zebrafish Model of Dravet Syndrome.  |  Dinday, MT. and Baraban, SC. 2015. eNeuro. 2: PMID: 26465006
  4. A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy.  |  Atkin, TA., et al. 2018. Epilepsia. 59: 802-813. PMID: 29574705
  5. A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry.  |  Gabriel, J., et al. 2019. Front Chem. 7: 665. PMID: 31637233
  6. A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease.  |  Wu, W., et al. 2020. Int J Mol Sci. 21: PMID: 32143538
  7. Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice.  |  Xu, X., et al. 2020. iScience. 23: 101617. PMID: 33089105
  8. YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity.  |  Zhu, C., et al. 2021. Pathogens. 10: PMID: 33672424
  9. Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway.  |  Zhang, W., et al. 2021. FEBS Open Bio. 11: 3032-3050. PMID: 34496154

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Drofenine hydrochloride, 100 mg

sc-234845A
100 mg
$275.00

Drofenine hydrochloride, 500 mg

sc-234845B
500 mg
$970.00

Drofenine hydrochloride, 1 g

sc-234845
1 g
$1635.00