Date published: 2025-12-6

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Drimentine A (CAS 204398-90-3)

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Application:
Drimentine A is a novel antibiotic with a terpenylated diketopiperazine structure
CAS Number:
204398-90-3
Molecular Weight:
503.72
Molecular Formula:
C32H45N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Drimentine A, bearing the CAS number 204398-90-3, is an intriguing chemical compound classified under the drimentines, a group known for their distinct bicyclic structure composed of fused pyrrolidine and oxazoline rings. This configuration is critical to its biological activity, particularly its role in modulating ion channels, a vital component in cellular signaling pathways. Drimentine A specifically interacts with and modulates the function of potassium channels, which are essential for maintaining the cellular membrane potential and regulating nerve impulse transmission. By altering the activity of these channels, Drimentine A can influence the excitability of cells, impacting how signals are transmitted within and between cells. This unique mechanism makes it a valuable tool in neuroscientific research, providing insights into the fundamental operations of ion channels within the nervous system and their role in various physiological processes. Researchers utilize Drimentine A to explore the structure-function relationships in ion channels, particularly how specific modifications in channel proteins affect their activity and interactions with small molecules. This research is crucial for understanding the complexities of neurological functions and could lead to the elucidation of mechanisms underlying various neurological disorders, contributing significantly to the field of neuropharmacology and cellular physiology.


Drimentine A (CAS 204398-90-3) References

  1. Hybrid isoprenoids from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64.  |  Che, Q., et al. 2012. Org Lett. 14: 3438-41. PMID: 22702354
  2. Total synthesis of indotertine A and drimentines A, F, and G.  |  Sun, Y., et al. 2013. Angew Chem Int Ed Engl. 52: 9201-4. PMID: 23857819
  3. Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery.  |  Yao, T., et al. 2018. Nat Commun. 9: 4091. PMID: 30291234
  4. Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A.  |  Kelly, SP., et al. 2022. J Am Chem Soc. 144: 19326-19336. PMID: 36223664
  5. Intermolecular Conjugate Addition of Pyrroloindoline and Furoindoline Radicals to α, β‐Unsaturated Enones via Photoredox Catalysis.  |  Zhou and Shupeng, et al. 2014. Advanced Synthesis & Catalysis. 356.13: 2867-2872.
  6. Mimicking the Main Events of the Biosynthesis of Drimentines: Synthesis of Δ8′‐Isodrimentine A and Related Compounds.  |  Skiredj and Adam, et al. 2016. European Journal of Organic Chemistry. 2016.17: 2954-2958.
  7. Harnessing the main event of drimentines biosynthesis: bio-inspired synthesis and biological evaluation of Δ8'-isodrimentine A and related compounds.  |  Skiredj and A., et al. 2016. Planta Medica. 82.S 01: P696.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Drimentine A, 1 mg

sc-391520
1 mg
$315.00