Molecular structure of DRF 2519
DRF 2519
Application:
DRF 2519 is a dual PPARα/γ agonist
Molecular Weight:
398.43
Molecular Formula:
C20H18N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DRF-2519 is a dual PPARα/γ activator. It has better reduction of plasma insulin, triglyceride, and free fatty acid levels than those treated with rosiglitazone.
DRF 2519 References
- Antidiabetic and hypolipidemic potential of DRF 2519--a dual activator of PPAR-alpha and PPAR-gamma. | Chakrabarti, R., et al. 2004. Eur J Pharmacol. 491: 195-206. PMID: 15140637
- Dual PPAR-alpha and -gamma activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential. | Madhavan, GR., et al. 2006. Bioorg Med Chem. 14: 584-91. PMID: 16198573
- PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome. | Fiévet, C., et al. 2006. Curr Opin Pharmacol. 6: 606-14. PMID: 16973418
- Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice. | Hu, X., et al. 2006. Acta Pharmacol Sin. 27: 1346-52. PMID: 17007742
- Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). | Guzman, ML., et al. 2007. Blood. 110: 4436-44. PMID: 17785584
- Effect of GCP-02, a PPARalpha/gamma dual activator, on glucose and lipid metabolism in insulin-resistant mice. | Wang, ZJ., et al. 2008. Eur J Pharmacol. 580: 277-83. PMID: 18048028
- Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease. | Belvisi, MG. and Mitchell, JA. 2009. Br J Pharmacol. 158: 994-1003. PMID: 19703165
- Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. | Pirat, C., et al. 2012. J Med Chem. 55: 4027-61. PMID: 22260081
- Correlation between activation of PPARγ and resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones. | Sotiriou, A., et al. 2013. Toxicol In Vitro. 27: 1425-32. PMID: 23563205
- Predictably selective (sp3)C-O bond formation through copper catalyzed dehydrogenative coupling: facile synthesis of dihydro-oxazinone derivatives. | Modak, A., et al. 2014. Org Lett. 16: 2602-5. PMID: 24761793
- Benzoxazine: A Privileged Scaffold in Medicinal Chemistry. | Tang, Z., et al. 2023. Curr Med Chem. 30: 372-389. PMID: 35792127
Activator of:
PPAR alpha, and PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DRF 2519, 25 mg | sc-300504 | 25 mg | $575.00 |