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DREAM Antibody (A-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects DREAM protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-DREAM antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DREAM protein, known as DRE-antagonist modulator, functions as a calcium-regulated transcriptional repressor that specifically binds to downstream regulatory elements (DRE), which are crucial for silencing basal transcription. This regulatory sequence is located in the promoter region of the gene encoding human prodynorphin, an opioid peptide that plays a significant role in memory acquisition and pain modulation. DREAM′s ability to form functional homotetramers is essential for DRE interaction, and this binding is highly sensitive to calcium levels; an increase in calcium concentration inhibits DREAM′s binding capacity, thereby blocking repressive activity. DREAM transcripts are predominantly found in the brain, thymus, and thyroid gland, where DREAM is expressed as a nuclear protein. DREAM has been shown to inhibit the transcription of other genes containing DRE-like motifs, including the gene for the AP-1 transcription factor c-Fos, indicating a broader influence on various cellular genes and pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DREAM Antibody (A-9) | sc-166916 | 200 µg/ml | $316.00 | |||
DREAM Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-525774 | 200 µg Ab; 10 µg BP | $354.00 | |||
DREAM Antibody (A-9): m-IgG2b BP-HRP Bundle | sc-549633 | 200 µg Ab; 10 µg BP | $354.00 | |||
DREAM Antibody (A-9) AC | sc-166916 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DREAM Antibody (A-9) HRP | sc-166916 HRP | 200 µg/ml | $316.00 | |||
DREAM Antibody (A-9) FITC | sc-166916 FITC | 200 µg/ml | $330.00 | |||
DREAM Antibody (A-9) PE | sc-166916 PE | 200 µg/ml | $343.00 | |||
DREAM Antibody (A-9) Alexa Fluor® 488 | sc-166916 AF488 | 200 µg/ml | $357.00 | |||
DREAM Antibody (A-9) Alexa Fluor® 546 | sc-166916 AF546 | 200 µg/ml | $357.00 | |||
DREAM Antibody (A-9) Alexa Fluor® 594 | sc-166916 AF594 | 200 µg/ml | $357.00 | |||
DREAM Antibody (A-9) Alexa Fluor® 647 | sc-166916 AF647 | 200 µg/ml | $357.00 | |||
DREAM Antibody (A-9) Alexa Fluor® 680 | sc-166916 AF680 | 200 µg/ml | $357.00 | |||
DREAM Antibody (A-9) Alexa Fluor® 790 | sc-166916 AF790 | 200 µg/ml | $357.00 |