Date published: 2026-4-3

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DRB (CAS 53-85-0)

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Alternate Names:
5,6-Dichlorobenzimidazole riboside; 5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole
Application:
DRB is an adenosine analogue which interrupts DNA transcription
CAS Number:
53-85-0
Purity:
≥98%
Molecular Weight:
319.14
Molecular Formula:
C12H12Cl2N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DRB, an adenosine analogue, may act to reduce Uridine (sc-296685) uptake in cells causing a premature termination of DNA transcription during the initiation phase. Mechanistic studies suggest that this compound acts as a mixed-type inhibitor with respect to casein kinase II and as a competitive inhibitor with respect to the nucleotide phosphate donor substrates. Experiments have noted that DRB can reversibly block germinal vesicle breakdown in bovine oocytes matured in vitro. DRB is an inhibitor of Cdk7, Cdk8 and Cdk9.


DRB (CAS 53-85-0) References

  1. Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia.  |  Levenson, J., et al. 2000. Proc Natl Acad Sci U S A. 97: 12858-63. PMID: 11050153
  2. 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes.  |  Mao, Y., et al. 2001. J Biol Chem. 276: 40652-8. PMID: 11546768
  3. A survey of the effect of metabolic antagonists on the synthesis of antibody in an in vitro system.  |  DUTTON, RW. and PEARCE, JD. 1962. Immunology. 5: 414-23. PMID: 13888737
  4. NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.  |  Li, X., et al. 2006. Mol Cell Biol. 26: 3008-17. PMID: 16581776
  5. Role of glucocorticoid receptor and CCAAT/enhancer-binding protein alpha in the feed-forward induction of 11beta-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts.  |  Yang, Z., et al. 2007. J Endocrinol. 195: 241-53. PMID: 17951535
  6. Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.  |  Grozav, AG., et al. 2009. Nucleic Acids Res. 37: 382-92. PMID: 19043076
  7. Long-term habituation of the gill-withdrawal reflex in aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels.  |  Esdin, J., et al. 2010. Front Behav Neurosci. 4: 181. PMID: 21152260
  8. hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.  |  Chang, HY., et al. 2011. Cancer Res. 71: 1126-34. PMID: 21266351
  9. Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition.  |  Liu, Y., et al. 2015. FEBS Lett. 589: 2233-40. PMID: 26183205
  10. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II.  |  Zandomeni, RO. 1989. Biochem J. 262: 469-73. PMID: 2803263
  11. Relationships between the structural and functional organization of the turtle cell nucleolus.  |  Bartholomé, O., et al. 2019. J Struct Biol. 208: 107398. PMID: 31585176
  12. Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.  |  Zandomeni, R., et al. 1986. J Biol Chem. 261: 3414-9. PMID: 3456346
  13. Mechanism of action of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery.  |  Mittleman, B., et al. 1983. J Mol Biol. 165: 461-73. PMID: 6188848
  14. Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription.  |  Zandomeni, R., et al. 1983. J Mol Biol. 167: 561-74. PMID: 6876157
  15. Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB).  |  Farin, CE. and Yang, L. 1994. Mol Reprod Dev. 37: 284-92. PMID: 8185933

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DRB, 10 mg

sc-200581
10 mg
$43.00

DRB, 50 mg

sc-200581A
50 mg
$189.00

DRB, 100 mg

sc-200581B
100 mg
$316.00

DRB, 250 mg

sc-200581C
250 mg
$663.00