DPPX Antibody (A-8): sc-365147

DPPX Antibody (A-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects DPPX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DPPX Antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DPPX, a single-pass type II membrane protein predominantly expressed in brain tissues, plays a crucial role in modulating the activity of voltage-gated potassium channels, particularly KCND2. This modulation influences neuronal excitability and signaling, which are vital for proper brain function. Dysregulation of DPPX and interactions with potassium channels can contribute to various neurological disorders, highlighting the importance of studying DPPX in the context of both health and disease. Dipeptidyl peptidases, including DPPX, cleave proline-containing dipeptides from the N-termini of proteins, and regulatory activities have been linked to conditions such as type 2 diabetes, obesity, and cancer. Understanding DPPX interactions and functions can provide insights into therapeutic targets for these diseases.

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DPPX Antibody (A-8) References:

1. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).  |  Jerng, HH., et al. 2004. Biophys J. 87: 2380-96. PMID: 15454437
2. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family.  |  Strop, P., et al. 2004. J Mol Biol. 343: 1055-65. PMID: 15476821
3. Molecular physiology and modulation of somatodendritic A-type potassium channels.  |  Jerng, HH., et al. 2004. Mol Cell Neurosci. 27: 343-69. PMID: 15555915
4. DPP10 modulates Kv4-mediated A-type potassium channels.  |  Zagha, E., et al. 2005. J Biol Chem. 280: 18853-61. PMID: 15671030
5. Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7.  |  Yokotani, N., et al. 1993. Hum Mol Genet. 2: 1037-9. PMID: 8103397

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DPPX Antibody (A-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DPPX Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DPPX Antibody (A-8) Specifications

Alternate Product Name: DPPX

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 668-744

Epitope Target: DPPX

Epitope Species: human

Product Reactivity/Detection: DPPX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DPPX Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin