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Doxycycline monohydrate (CAS 17086-28-1)

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Application:
Doxycycline monohydrate is an antimicrobial agent and a matrix metalloproteinase inhibitor
CAS Number:
17086-28-1
Purity:
≥98%
Molecular Weight:
462.45
Molecular Formula:
C22H24N2O8•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Doxycycline monohydrate is a broad-spectrum compound extensively studied in the field of biochemistry and molecular biology. In research applications, it is often used as a tool to explore the inhibition of protein synthesis in prokaryotic cells, which can provide insights into the mechanisms of ribosomal function. Additionally, the compound is applied in the study of gene expression, where it acts as a regulator in inducible gene expression systems in both bacterial and mammalian cells. This ability to control gene expression makes Doxycycline monohydrate valuable for investigating gene function and the molecular pathways within cells. It is also used in the study of metalloproteinase (MMP) inhibitors, as it is known to affect the expression and activity of these enzymes that are involved in the degradation of extracellular matrix components. Research involving Doxycycline monohydrate also encompasses its role in the elucidation of microbial resistance mechanisms.


Doxycycline monohydrate (CAS 17086-28-1) References

  1. Susceptibility of bacteria from feline and canine urinary tract infections to doxycycline and tetracycline concentrations attained in urine four hours after oral dosage.  |  Wilson, BJ., et al. 2006. Aust Vet J. 84: 8-11. PMID: 16498827
  2. Update on rosacea and anti-inflammatory-dose doxycycline.  |  Berman, B., et al. 2007. Drugs Today (Barc). 43: 27-34. PMID: 17315050
  3. Lupus Miliaris Disseminatus Faciei With Isolated Axillary Involvement.  |  Kim, WB. and Mistry, N. 2016. J Cutan Med Surg. 20: 153-4. PMID: 26471742
  4. Subantimicrobial-dose doxycycline monohydrate in dermatology.  |  Wollina, U. 2015. Wien Med Wochenschr. 165: 499-503. PMID: 26564206
  5. Enteric Coating Reduces Upper Gastrointestinal Adverse Reactions to Doxycycline.  |  Järvinen, A., et al. 1995. Clin Drug Investig. 10: 323-7. PMID: 27519332
  6. Application of Metal-Organic Framework Nano-MIL-100(Fe) for Sustainable Release of Doxycycline and Tetracycline.  |  Taherzade, SD., et al. 2017. Nanomaterials (Basel). 7: PMID: 28783087
  7. Morbihan disease: successful treatment with slow-releasing doxycycline monohydrate.  |  Chaidemenos, G., et al. 2018. J Eur Acad Dermatol Venereol. 32: e68-e69. PMID: 28833773
  8. Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study.  |  Dadras Chomachayi, M., et al. 2018. J Biomed Mater Res A. 106: 1092-1103. PMID: 29210169
  9. Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats.  |  Carvalho, LD., et al. 2019. J Appl Oral Sci. 27: e20180663. PMID: 31596368
  10. On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified?  |  Azad, MA., et al. 2019. Pharm Res. 36: 167. PMID: 31650274
  11. Doxycycline-Associated Dual Cutaneous Adverse Reaction to the Drug (CARD): Case Report of Concurrent Photosensitivity and Morbilliform Exanthem to Doxycycline.  |  Jacob, JS. and Cohen, PR. 2020. Cureus. 12: e11546. PMID: 33365215
  12. Clinical and laboratory assessment of the role of the conditionally pathogenic sexually transmitted flora in the formation of the pathological state of the cervix and cervical canal in women of reproductive age.  |  Abdrakhmanov, AR. and Abdrakhmanov, RM. 2022. Minerva Obstet Gynecol. 74: 60-67. PMID: 35196853
  13. Doxycycline-Associated Hyperpigmentation: A Case Report and Literature Review.  |  Afrin, A. and Cohen, PR. 2022. Cureus. 14: e23754. PMID: 35509754
  14. Antibiotic prescribing trends in primary care 2014-2022.  |  McCloskey, AP., et al. 2023. Res Social Adm Pharm.. PMID: 37183105
  15. Bioavailability of doxycycline monohydrate. A comparison with equivalent doses of doxycycline hydrochloride.  |  Malmborg, AS. 1984. Chemotherapy. 30: 76-80. PMID: 6697815

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Doxycycline monohydrate, 5 g

sc-263109
5 g
$73.00

Doxycycline monohydrate, 25 g

sc-263109A
25 g
$200.00

Can this compound be used for cell culture?

Asked by: two2igm05
Thank you for your question. Doxycycline monohydrate cannot be used for cell culture.
Answered by: Technical Support
Date published: 2017-02-23
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Rated 5 out of 5 by from Duivenvoorden WC; et alDuivenvoorden WC; et al. (PubMed ID: 9949290) Doxycycline monohydrate has cytotoxic activity against some breast cancer cell lines. -SCBT Publication Review
Date published: 2015-04-26
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Doxycycline monohydrate is rated 5.0 out of 5 by 1.
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