Molecular structure of Doxorubicinone, CAS Number: 24385-10-2
Doxorubicinone (CAS 24385-10-2)
Alternate Names:
Adriamycin Aglycone; Epirubicin EP Impurity A
Application:
Doxorubicinone is a metabolite of Doxorubicin (Dx)
CAS Number:
24385-10-2
Molecular Weight:
414.36
Molecular Formula:
C21H18O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Doxorubicinone, an anthracycline analog, is pivotal in chemical and biochemical research for its role in DNA intercalation studies, which are for understanding the molecular basis of anthracycline activity. Serving as a valuable intermediate in the synthesis of novel compounds, it enables the exploration of structural modifications and their impact on biological function. Its quinone structure is particularly useful in the study of redox cycling and free radical generation, key processes in cellular oxidative stress, and it is also instrumental in the examination of specific enzyme interactions within these pathways.
Doxorubicinone (CAS 24385-10-2) References
- Determination of doxorubicin and its metabolites in rat serum and bile by LC: application to preclinical pharmacokinetic studies. | Zhou, Q. and Chowbay, B. 2002. J Pharm Biomed Anal. 30: 1063-74. PMID: 12408897
- Subcellular metabolite profiles of the parent CCRF-CEM and the derived CEM/C2 cell lines after treatment with doxorubicin. | Anderson, AB. and Arriaga, EA. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 808: 295-302. PMID: 15261824
- Optimization of a liquid chromatographic separation for the simultaneous determination of four anthracyclines and their respective 13-S-dihydro metabolites. | Maudens, KE., et al. 2008. J Sep Sci. 31: 1042-9. PMID: 18306207
- Doxorubicin toxicity and pharmacokinetics in old and young rats. | Colombo, T., et al. 1989. Exp Gerontol. 24: 159-71. PMID: 2721604
- Investigations into the DNA-binding mode of doxorubicinone. | Tartakoff, SS., et al. 2019. Org Biomol Chem. 17: 1992-1998. PMID: 30406253
- Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Determination of Doxorubicin and its Metabolites Doxorubicinol, Doxorubicinone, Doxorubicinolone, and 7-Deoxydoxorubicinone in Mouse Plasma. | Choi, WG., et al. 2020. Molecules. 25: PMID: 32164308
- Intra-tumoral drug concentration mapping within solid tumor micro-milieu using in-vitro model and doxorubicin as a model drug. | Al-Abd, AM., et al. 2020. Saudi Pharm J. 28: 754-762. PMID: 32550808
- Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids. | Huseman, ED., et al. 2021. ACS Cent Sci. 7: 1327-1337. PMID: 34471677
- Analysis of doxorubicin, 4'-epidoxorubicin, and their metabolites by liquid chromatography. | Weenen, H., et al. 1986. J Pharm Sci. 75: 1201-4. PMID: 3470504
- High-Throughput Method for the Simultaneous Determination of Doxorubicin Metabolites in Rat Urine after Treatment with Different Drug Nanoformulations. | Zorić, L., et al. 2022. Molecules. 27: PMID: 35208967
- Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics. | Qian, L., et al. 2022. ACS Chem Biol. 17: 1665-1671. PMID: 35687750
- DNA damage independent inhibition of NF-κB transcription by anthracyclines. | Chora, AF., et al. 2022. Elife. 11: PMID: 36476511
- A sensitive and simple high-performance liquid chromatographic method for the determination of doxorubicin and its metabolites in plasma. | Andersen, A., et al. 1993. Ther Drug Monit. 15: 455-61. PMID: 8249054
- A sensitive procedure for the quantitation of free and N-(2-hydroxypropyl) methacrylamide polymer-bound doxorubicin (PK1) and some of its metabolites, 13-dihydrodoxorubicin, 13-dihydrodoxorubicinone and doxorubicinone, in human plasma and urine by reversed-phase HPLC with fluorimetric detection. | Fraier, D., et al. 1995. J Pharm Biomed Anal. 13: 625-33. PMID: 9696578
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doxorubicinone, 2 mg | sc-218273 | 2 mg | $370.00 | |||
Doxorubicinone, 10 mg | sc-218273A | 10 mg | $1817.00 | |||
Doxorubicinone, 25 mg | sc-218273B | 25 mg | $3127.00 | |||
Doxorubicinone, 50 mg | sc-218273C | 50 mg | $5520.00 | |||
Doxorubicinone, 100 mg | sc-218273D | 100 mg | $8329.00 | |||
Doxorubicinone, 1 g | sc-218273E | 1 g | $27057.00 | |||
Doxorubicinone, 10 g | sc-218273F | 10 g | $70753.00 |