Molecular structure of Doxorubicinol, CAS Number: 54193-28-1
Doxorubicinol (CAS 54193-28-1)
See product citations (4)
Alternate Names:
Doxorubicinol is also known as
Application:
Doxorubicinol is an antineoplastic agent
CAS Number:
54193-28-1
Molecular Weight:
545.54
Molecular Formula:
C27H31NO11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Doxorubicinol is a metabolite of doxorubicin and is studied in research applications for its chemical kinetics and metabolism. The focus of research on Doxorubicinol revolves around its formation and clearance as part of the metabolic pathway of its parent compound. Investigations are conducted to understand the biotransformation that leads to the production of Doxorubicinol to gain insights into the compound′s efficacy and the mechanisms underlying its metabolism. Studies typically examine how Doxorubicinol interacts with cellular targets and its potential role in the generation of reactive oxygen species, which can contribute to cellular oxidative stress.
Doxorubicinol (CAS 54193-28-1) References
- Effects of doxorubicinol on excitation--contraction coupling in guinea pig ventricular myocytes. | Wang, GX., et al. 2001. Eur J Pharmacol. 423: 99-107. PMID: 11448472
- A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979). | Callies, S., et al. 2003. Cancer Chemother Pharmacol. 51: 107-18. PMID: 12647011
- Toxicokinetics of the active doxorubicin metabolite, doxorubicinol, in sulphur-crested cockatoos (Cacatua galerita). | Gilbert, CM., et al. 2007. Res Vet Sci. 83: 123-9. PMID: 17197005
- Quantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electrospray tandem mass spectroscopy: Application to preclinical pharmacokinetic studies. | Liu, Y., et al. 2008. Talanta. 74: 887-95. PMID: 18371724
- Doxorubicin and doxorubicinol: intra- and inter-individual variations of pharmacokinetic parameters. | Jacquet, JM., et al. 1990. Cancer Chemother Pharmacol. 27: 219-25. PMID: 2265458
- Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3. | Schaupp, CM., et al. 2015. Chem Biol Interact. 234: 154-61. PMID: 25446851
- Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. | Olson, RD., et al. 1988. Proc Natl Acad Sci U S A. 85: 3585-9. PMID: 2897122
- Effect of phenytoin on the pharmacokinetics of doxorubicin and doxorubicinol in the rabbit. | Cusack, BJ., et al. 1988. Cancer Chemother Pharmacol. 22: 294-8. PMID: 3168142
- Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified. | Breysse, DH., et al. 2020. Drug Metab Dispos. 48: 187-197. PMID: 31955137
- Exogenous doxorubicinol induces cardiotoxic effects in rats. | Danesi, R., et al. 1987. Eur J Cancer Clin Oncol. 23: 907-13. PMID: 3665998
- Pharmacokinetics of doxorubicin and its metabolite doxorubicinol in rabbits with induced acid and alkaline urine. | Johansen, PB., et al. 1984. Cancer Chemother Pharmacol. 13: 5-8. PMID: 6329539
- Time-related increases in cardiac concentrations of doxorubicinol could interact with doxorubicin to depress myocardial contractile function. | Mushlin, PS., et al. 1993. Br J Pharmacol. 110: 975-82. PMID: 8298821
- Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit. | Cusack, BJ., et al. 1993. Cancer Chemother Pharmacol. 32: 53-8. PMID: 8462124
- Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice. | Webster, LK., et al. 1996. Br J Cancer. 73: 522-4. PMID: 8595168
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doxorubicinol, 2.5 mg | sc-495904 | 2.5 mg | $357.00 | |||
Doxorubicinol, 25 mg | sc-495904A | 25 mg | $2497.00 |