Doxorubicin hydrochloride (CAS 25316-40-9)
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Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once Doxorubicin hydrochloride associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives Doxorubicin hydrochloride efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin hydrochloride. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR. Doxorubicin hydrochloride is also known as Hydroxydaunorubicin Hydrochloride, DOX, and (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride.
Doxorubicin hydrochloride (CAS 25316-40-9) References
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- pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride. | Du, Y., et al. 2012. Biomaterials. 33: 7291-9. PMID: 22795540
- Development and characterization of liposomal doxorubicin hydrochloride with palm oil. | Sabeti, B., et al. 2014. Biomed Res Int. 2014: 765426. PMID: 24795894
- Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies. | Wu, S., et al. 2013. Materials (Basel). 6: 2026-2042. PMID: 28809258
- Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride. | Gagliardi, A., et al. 2020. Pharmaceutics. 12: PMID: 33114287
- Optical Properties of Doxorubicin Hydrochloride Load and Release on Silica Nanoparticle Platform. | Nguyen, TN., et al. 2021. Molecules. 26: PMID: 34209621
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doxorubicin hydrochloride, 5 mg | sc-200923 | 5 mg | $85.00 | |||
Doxorubicin hydrochloride, 10 mg | sc-200923B | 10 mg | $150.00 | |||
Doxorubicin hydrochloride, 25 mg | sc-200923A | 25 mg | $210.00 | |||
Doxorubicin hydrochloride, 100 mg | sc-200923C | 100 mg | $290.00 | |||
Doxorubicin hydrochloride, 250 mg | sc-200923D | 250 mg | $520.00 |