Molecular structure of Doxofylline, CAS Number: 69975-86-6
Doxofylline (CAS 69975-86-6)
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Application:
Doxofylline is a xanthine bronchodilator known to impede phosphodiesterase activities
CAS Number:
69975-86-6
Purity:
≥99%
Molecular Weight:
266.25
Molecular Formula:
C11H14N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Doxofylline (CAS 69975-86-6) is a xanthine derivative, part of a broader class of compounds known for their various biochemical and physiological properties. Chemically distinct from other members of its class by specific molecular modifications, doxofylline features a unique structure that influences its interaction with various biochemical pathways and enzymes. Doxofylline′s action on adenosine receptors and its minimal effect on phosphodiesterase enzymes make it a valuable subject for studying the regulation of intracellular signaling pathways. Its distinctive mechanism offers a basis for exploring how modifications in xanthine molecules can alter their interaction with cellular targets and affect signaling cascades involved in cellular functions.
Doxofylline (CAS 69975-86-6) References
- Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects. | Dini, FL. and Cogo, R. 2001. Curr Med Res Opin. 16: 258-68. PMID: 11268710
- Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse. | Riffo-Vasquez, Y., et al. 2014. Pulm Pharmacol Ther. 27: 170-8. PMID: 24456641
- Doxofylline in rat brain in relation to locomotor activity. | Cravanzola, C., et al. 1989. Drug Metab Dispos. 17: 437-40. PMID: 2571486
- Steroid sparing effects of doxofylline. | Riffo-Vasquez, Y., et al. 2018. Pulm Pharmacol Ther. 48: 1-4. PMID: 29031617
- Impact of doxofylline compared to theophylline in asthma: A pooled analysis of functional and clinical outcomes from two multicentre, double-blind, randomized studies (DOROTHEO 1 and DOROTHEO 2). | Calzetta, L., et al. 2018. Pulm Pharmacol Ther. 53: 20-26. PMID: 30219705
- Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis. | Rogliani, P., et al. 2019. Multidiscip Respir Med. 14: 25. PMID: 31388422
- Comparison of anti-inflammatory mechanisms between doxofylline and theophylline in human monocytes. | Talmon, M., et al. 2019. Pulm Pharmacol Ther. 59: 101851. PMID: 31563516
- The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells. | Jiao, P., et al. 2020. Artif Cells Nanomed Biotechnol. 48: 687-694. PMID: 32098511
- Biophysical insight into the binding mechanism of doxofylline to bovine serum albumin: An in vitro and in silico approach. | Siddiqui, S., et al. 2021. Spectrochim Acta A Mol Biomol Spectrosc. 249: 119296. PMID: 33338935
- Effect of terbutaline plus doxofylline on chronic obstructive pulmonary disease. | Luo, Q., et al. 2021. Am J Transl Res. 13: 6959-6965. PMID: 34306449
- Effects of Doxofylline Combined with Ceftazidime on Clinical Efficacy, Drug Safety, and Prognosis in Patients with Chronic Obstructive Pulmonary Disease Complicated with Infection. | Wang, Y. 2021. Med Sci Monit. 27: e930494. PMID: 34404757
- Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD. | Chen, ZY., et al. 2022. BMC Pulm Med. 22: 66. PMID: 35177065
- Doxofylline in acute exacerbation of chronic obstructive pulmonary disease. | Sevik, OE. and Canakci, ME. 2022. Rev Assoc Med Bras (1992). 68: 302. PMID: 35442353
- Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway. | Xu, L., et al. 2023. Front Pharmacol. 14: 1135366. PMID: 37007035
- Studying the Mechanism of Interaction of Doxofylline with Human Lysozyme: A Biophysical and In Silico Approach. | Alomar, SY. 2023. Molecules. 28: PMID: 37110695
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PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doxofylline, 1 g | sc-205658 | 1 g | $82.00 | |||
Doxofylline, 5 g | sc-205658A | 5 g | $224.00 |