Date published: 2025-11-1

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Dovitinib Dilactic acid (CAS 852433-84-2)

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Application:
Dovitinib Dilactic acid is a growth factor receptor kinase inhibitor that targets Flt-3, c-KIT, PDGFR, and CSF
CAS Number:
852433-84-2
Purity:
≥99%
Molecular Weight:
572.59
Molecular Formula:
C21H21FN6O•2C3H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dovitinib Dilactic acid, also known scientifically as TKI258 Dilactic acid, is a potent and selective inhibitor of receptor tyrosine kinases (RTKs), which play a role in the signaling pathways that regulate cell proliferation and survival. Its mechanism of action is centered on the inhibition of multiple RTK families, including the fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor (VEGFR), and platelet-derived growth factor receptor (PDGFR) families. This broad spectrum of activity allows Dovitinib Dilactic acid to interfere with the angiogenic processes and tumor growth by blocking the signaling pathways that are essential for the development and maintenance of blood vessels in tumors, as well as the pathways involved in the proliferation and survival of cancer cells. In research applications, Dovitinib Dilactic acid serves as useful for studying the role of RTKs in various cellular processes and disease states, particularly in the field of oncology, where understanding the molecular basis of tumor growth and progression is critical for the development of new therapeutic strategies.


Dovitinib Dilactic acid (CAS 852433-84-2) References

  1. Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model.  |  Kähkönen, TE., et al. 2019. J Bone Oncol. 16: 100232. PMID: 30956945
  2. TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer.  |  Sohn, SH., et al. 2021. J Cancer. 12: 6356-6362. PMID: 34659525
  3. Entrectinib Induces Apoptosis and Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer with NTRK Overexpression.  |  Sohn, SH., et al. 2021. Int J Mol Sci. 23: PMID: 35008821
  4. Engineering high throughput screening platforms of cervical cancer.  |  Cadena, IA., et al. 2023. J Biomed Mater Res A. 111: 747-764. PMID: 36861788

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dovitinib Dilactic acid, 10 mg

sc-364484
10 mg
$299.00

Dovitinib Dilactic acid, 25 mg

sc-364484A
25 mg
$470.00