DOTAP mesylate (CAS 252769-92-9)
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DOTAP mesylate is a cationic lipid used development for its ability to facilitate the delivery of nucleic acids into cells. Its mode of action involves electrostatic interactions with negatively charged nucleic acids, forming stable complexes known as lipoplexes. These lipoplexes can fuse with the cell membrane, allowing the nucleic acids to enter the cell and exert their effects. DOTAP mesylate may enhance endosomal escape, promoting the release of nucleic acids into the cytoplasm where they can exert their biological function. This lipid′s function in facilitating nucleic acid delivery in the study of gene expression, gene silencing, and gene editing. Its ability to efficiently deliver nucleic acids into cells without inducing significant cytotoxicity makes it a useful component in various experimental applications aimed at manipulating cellular processes at the molecular level.
DOTAP mesylate (CAS 252769-92-9) References
- Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles. | Leventis, R. and Silvius, JR. 1990. Biochim Biophys Acta. 1023: 124-32. PMID: 2317491
- Multicomponent Lipid Nanoparticles for RNA Transfection. | Gretskaya, N., et al. 2023. Pharmaceutics. 15: PMID: 37111773
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DOTAP mesylate, 5 mg | sc-202589 | 5 mg | $51.00 | |||
DOTAP mesylate, 25 mg | sc-202589A | 25 mg | $204.00 |