Doripenem (CAS 148016-81-3)

Doripenem, with the CAS number 148016-81-3, is a synthetic carbapenem antibiotic that represents a subclass of β-lactam antibiotics noted for their broad-spectrum activity. The core mechanism by which doripenem exerts its action is through the inhibition of bacterial cell wall synthesis. This is achieved by its binding to penicillin-binding proteins (PBPs), which are essential enzymes involved in the cross-linking process that provides mechanical strength to the bacterial cell wall. By inhibiting these PBPs, doripenem disrupts cell wall integrity, leading to cell lysis and ultimately, bacterial cell death. In research environments, doripenem has been extensively used to study bacterial resistance mechanisms against β-lactam antibiotics. Its role in understanding the kinetics and dynamics of PBP inhibition, and the subsequent effects on bacterial cell viability, provides valuable insights into the design of more effective antibacterial strategies. Additionally, the compound has been pivotal in studying the genetic mutations that confer resistance to carbapenems, particularly in the context of the spread of carbapenem-resistant Enterobacteriaceae. This research is crucial for developing diagnostic tools and novel therapeutic approaches to combat antibiotic-resistant bacterial infections, enhancing the global effort to manage and control the spread of resistant pathogens.