Molecular structure of Doramapimod, CAS Number: 285983-48-4
Doramapimod (CAS 285983-48-4)
See product citations (2)
Alternate Names:
BIRB 796; 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
Application:
Doramapimod is a potent p38α MAPK and JNK2 inhibitor
CAS Number:
285983-48-4
Purity:
≥98%
Molecular Weight:
527.66
Molecular Formula:
C31H37N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Doramapimod is a highly selective p38alpha MAPK inhibitor to TNF-alpha with EC50 of 18 nM. At 10 muM, doramapimod inhibits JNK2 in vitro, but at the low concentration necessary to inhibit p38alpha, it does not affect the phosphorylation of JNK substrates in cells. Doramapimod is an inhibitor of Raf-1.
Doramapimod (CAS 285983-48-4) References
- Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. | af Gennäs, GB., et al. 2011. ChemMedChem. 6: 1680-92. PMID: 21721129
- In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity. | Moon, SH., et al. 2015. J Pharmacol Sci. 129: 135-42. PMID: 26232862
- p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells. | Browne, AJ., et al. 2016. Cell Death Dis. 7: e2119. PMID: 26913608
- Human p38α mitogen-activated protein kinase in the Asp168-Phe169-Gly170-in (DFG-in) state can bind allosteric inhibitor Doramapimod. | Suplatov, D., et al. 2019. J Biomol Struct Dyn. 37: 2049-2060. PMID: 29749295
- Doxorubicin as a fluorescent reporter identifies novel MRP1 (ABCC1) inhibitors missed by calcein-based high content screening of anticancer agents. | Sampson, A., et al. 2019. Biomed Pharmacother. 118: 109289. PMID: 31401398
- Anti-inflammatory effects of a p38 MAP kinase inhibitor, doramapimod, against bacterial cell wall toxins in equine whole blood. | Bauquier, JR., et al. 2020. Vet Immunol Immunopathol. 220: 109994. PMID: 31877483
- Effect of the p38 MAPK inhibitor doramapimod on the systemic inflammatory response to intravenous lipopolysaccharide in horses. | Bauquier, J., et al. 2020. J Vet Intern Med. 34: 2109-2116. PMID: 32700419
- Chemical p38 MAP kinase inhibition constrains tissue inflammation and improves antibiotic activity in Mycobacterium tuberculosis-infected mice. | Hölscher, C., et al. 2020. Sci Rep. 10: 13629. PMID: 32788581
- p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-β. | Chen, S., et al. 2021. Int Immunopharmacol. 98: 107848. PMID: 34126342
- Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages. | Su, RC., et al. 2021. Int J Mol Sci. 22: PMID: 34576099
- DDX46 accelerates the proliferation of glioblastoma by activating the MAPK-p38 signaling. | Ma, J., et al. 2021. J BUON. 26: 2084-2089. PMID: 34761620
- Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro. | Raymonda, MH., et al. 2022. Virology. 566: 60-68. PMID: 34871905
- Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia. | Kurtz, SE., et al. 2022. Blood Adv. 6: 3062-3067. PMID: 35078224
Inhibitor of:
1700113H08Rik, APEG1, C-TAK1, C-TAK1L, C1sb, C230096C10Rik, CNK2, DCAMKL3, DUSP22, FAM122C, FAM44C, FAM75A3, Fus3, HUNK, IL-1RAcP, JNK1, JNK2, JNK3, KIAA0701, KIAA1430_4933411K20Rik, LHX2, LPPR2, LTβR, MADD, MAP3K6, MAPBPIP, MAPK15, MAPKAPK-2, MAPKBP-1, MAST205, MEK kinase-4, MEK-3, MEK3, Mkk2, Mxi 2, Nkx-6.1, Olfr54, Olfr543, Olfr594, Olfr630, OTTMUSG00000011282, OTTMUSG00000012817, OTTMUSG00000016327, p38, p38 alpha, p38γ MAPK12, p49/STRAP, Pap20, Pbs2, PRAK, Raf-1, RELL2, Sam 68, Ser/Thr Protein Kinase, SKRP1, SPRED3, SSEA-3, SSH2, SVOPL, T2BP, TBX18, Tnfrsf26, and TREML6.Activator of:
3pK, ALY, Bex5, C-TAK1L, C030039L03Rik, Cripto, Dab2, ERBIN, GOLGA6L, GRB7, MEK-6, PP2A-B56-δ, and Ron.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doramapimod, 25 mg | sc-300502 | 25 mg | $149.00 | |||
Doramapimod, 50 mg | sc-300502A | 50 mg | $281.00 | |||
Doramapimod, 100 mg | sc-300502B | 100 mg | $459.00 |