Date published: 2026-4-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

Dopamine 4-O-Sulfate (CAS 38339-02-5)

0.0(0)
Write a reviewAsk a question

Alternate Names:
4-(2-Aminoethyl)-1,2-benzenediol 1-(Hydrogen Sulfate); 3-Hydroxytyramine-4-O-sulfate; Dopamine Sulfate
CAS Number:
38339-02-5
Molecular Weight:
233.24
Molecular Formula:
C8H11NO5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Dopamine 4-O-sulfate (D4S) is a metabolite derived from dopamine, a neurotransmitter in the central nervous system. The enzyme sulfotransferase catalyzes the sulfation process to produce Dopamine 4-O-sulfate. Researchers are highly interested in synthesizing Dopamine 4-O-sulfate due to its potential impact on various physiological and pathological processes. Scientific investigations have extensively explored the role of Dopamine 4-O-sulfate, particularly its influence on dopamine signaling regulation. Dopamine 4-O-sulfate′s alters dopamine receptor conformation through binding, subsequently affecting downstream signaling pathways activated by these receptors.


Dopamine 4-O-Sulfate (CAS 38339-02-5) References

  1. Electron paramagnetic resonance study on free radical scavenging and/or generating activity of dopamine-4-O-sulfate.  |  Kirima, K., et al. 2001. Chem Pharm Bull (Tokyo). 49: 576-80. PMID: 11383609
  2. Urinary dopamine sulfate: regulations and significance in neurological disorders.  |  Kienzl, E., et al. 1990. J Neural Transm Suppl. 32: 471-9. PMID: 2089110
  3. Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates.  |  Suominen, T., et al. 2013. PLoS One. 8: e68007. PMID: 23826355
  4. Orchestration of salivary secretion mediated by two different dopamine receptors in the blacklegged tick Ixodes scapularis.  |  Kim, D., et al. 2014. J Exp Biol. 217: 3656-63. PMID: 25320269
  5. Contents of dopamine sulfoconjugate isomers and their desulfation in dog arteries.  |  Hashizume, K., et al. 1989. Biochem Pharmacol. 38: 1891-5. PMID: 2742597
  6. Modified syntheses of dopamine-4-sulfate, epinephrine-3-sulfate, and norepinephrine-3-sulfate: determination of the position of the sulfate group by 1H-NMR spectroscopy.  |  Lernhardt, U., et al. 1988. Int J Sports Med. 9 Suppl 2: S89-92. PMID: 3182167
  7. Preparation of dopamine 3-O-sulphate and dopamine 4-O-sulphate as reference substances and high-performance liquid chromatographic trace determination.  |  Kienzl, E. and Eichinger, K. 1988. J Chromatogr. 430: 263-9. PMID: 3235502
  8. Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer.  |  Li, X., et al. 2020. PeerJ. 8: e10182. PMID: 33240601
  9. Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension.  |  Hashizume, K., et al. 1988. Clin Exp Hypertens A. 10: 561-74. PMID: 3390960
  10. Molecular Insights into SARS-CoV2-Induced Alterations of the Gut/Brain Axis.  |  Nataf, S. and Pays, L. 2021. Int J Mol Sci. 22: PMID: 34638785
  11. Direct measurement of dopamine O-sulfate in plasma and cerebrospinal fluid.  |  Scott, MC. and Elchisak, MA. 1987. J Chromatogr. 413: 17-23. PMID: 3558665
  12. Determination of dopamine-3- and 4-O-sulphate in human plasma and urine by anion-exchange high-performance liquid chromatography with fluorimetric detection.  |  Yamamoto, T., et al. 1985. J Chromatogr. 342: 261-7. PMID: 4055948
  13. Dopamine-4-O-sulfate: a possible precursor of free norepinephrine.  |  Buu, NT. and Kuchel, O. 1979. Can J Biochem. 57: 1159-62. PMID: 509357
  14. High-performance liquid chromatographic determination of dopamine sulfoconjugates in urine after L-dopa administration.  |  Arakawa, Y., et al. 1979. J Chromatogr. 162: 311-8. PMID: 528597
  15. Pharmacological characterization of dopamine-4-O-sulfate.  |  Ackerman, DM., et al. 1984. Arch Int Pharmacodyn Ther. 267: 241-8. PMID: 6712357

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dopamine 4-O-Sulfate, 10 mg

sc-496318
10 mg
$311.00