Donepezil hydrochloride CAS: 120011-70-3
MF: C24H29NO3•HCl
MW: 415.96
A noncompetitive acetylcholinesterase (AChE) inhibitor.

Donepezil hydrochloride (CAS 120011-70-3)

Donepezil hydrochloride | CAS 120011-70-3 is rated 5.0 out of 5 by 1.
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Alternate Names: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1H-inden-1-one; 2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride
Application: Donepezil hydrochloride is a noncompetitive acetylcholinesterase (AChE) inhibitor
CAS Number: 120011-70-3
Molecular Weight: 415.96
Molecular Formula: C24H29NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine.


References

1. Shintani, E.Y., et al. 1997. Am J Health Syst Pharm. 54: 2805-2810. PMID: 9428950
2. Bryson, H.M. and Benfield, P. 1997. Drugs Aging. 10: 234-240. PMID: 9108896

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (100 mM), DMSO (1 mg/ml), methanol, ethanol (2 mg/ml), and DMF (slightly).
Storage :
Store at -20° C
Melting Point :
223-227° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5741
MDL Number :
MFCD00881312
SMILES :
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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Donepezil hydrochloride (CAS 120011-70-3)  Product Citations

See how others have used Donepezil hydrochloride (CAS 120011-70-3). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27855959  Liew, KF.|Hanapi, NA.|Chan, KL.|Yusof, SR.|Lee, CY.| et al. 2017. J Pharm Sci. 106: 502-510.

PMID: # 30466001  Biomed Pharmacother. 118-128.

PMID: # 31866203  Dev. Cell.

PMID: # 25455147  J Nat Prod. 2716-9.

PMID: # 32831882  Evid Based Complement Alternat Med. 9058135.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Day J; et al Day J; et al. (PubMed ID: 25519950) Determined that Donepezil hydrochloride contributed in the treatmeant of cognitive insufficient adults with primary or metastatic brain tumors. -SCBT Publication Review
Date published: 2015-02-18
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