Donepezil hydrochloride (CAS 120011-70-3)
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Donepezil Hydrochloride is a piperidine derivative and a noncompetitive AChE (acetylcholinesterase) inhibitor (IC50 = 11.6 nM). Studies indicate that donepezil hydrochloride selectively inhibits AChE (acetylcholinesterase), whereas it has little effect on butyrylcholinesterase. Donepezil binds to hydrophobic sites on the AChE enzyme without altering the structure of either the enzyme or the inhibitor, allowing for a dynamic process of inhibition This mechanism of action prevents the breakdown of acetylcholine. Alternate studies suggest that donepezil hydrochloride increases the concentration of extracellular acetylcholine. Acetylcholine is a neurotransmitter involved in memory and learning processes. Donepezil Hydrochloride′s metabolic process involves cytochrome P450 enzymes.
Donepezil hydrochloride (CAS 120011-70-3) References
- Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. | Sugimoto, H., et al. 2000. Curr Med Chem. 7: 303-39. PMID: 10637367
- Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor. | Sugimoto, H., et al. 2002. Jpn J Pharmacol. 89: 7-20. PMID: 12083745
- Donepezil: an update. | Seltzer, B. 2007. Expert Opin Pharmacother. 8: 1011-23. PMID: 17472546
- Donepezil hydrochloride as a novel inducer for osteogenic differentiation of mesenchymal stem cells on PLLA scaffolds in vitro. | Soraya, Z., et al. 2021. Biotechnol J. 16: e2100112. PMID: 34170068
- A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia. | Yang, Q., et al. 2022. Medicine (Baltimore). 101: e29307. PMID: 35945739
- Donepezil. | Bryson, HM. and Benfield, P. 1997. Drugs Aging. 10: 234-9; discussion 240-1. PMID: 9108896
- Donepezil: an anticholinesterase inhibitor for Alzheimer's disease. | Shintani, EY. and Uchida, KM. 1997. Am J Health Syst Pharm. 54: 2805-10. PMID: 9428950
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Donepezil hydrochloride, 10 mg | sc-218265 | 10 mg | $97.00 | |||
Donepezil hydrochloride, 100 mg | sc-218265A | 100 mg | $202.00 |