Date published: 2026-2-9

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Dodecyl Methanethiosulfonate (CAS 355803-77-9)

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Alternate Names:
Methanesulfonothioic Acid S-Dodecyl Ester
Application:
Dodecyl Methanethiosulfonate is used to probe the structures of the ACh receptor channel
CAS Number:
355803-77-9
Molecular Weight:
280.49
Molecular Formula:
C13H28O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dodecyl Methanethiosulfonate specifically and rapidly reacts with thiols to form mixed disulfides. Dodecyl Methanethiosulfonate is used to probe the structures of the ACh receptor channel, of the GABA receptor channel, and of lactose permease.Dodecyl Methanethiosulfonate, known as DMTS, serves as a potent organic compound with diverse applications in scientific investigations. Functioning as a zwitterionic surfactant, DMTS possesses both hydrophilic and hydrophobic ends, enabling its utility across a wide array of tasks. In recent decades, intensive studies have unveiled numerous biochemical and physiological impacts of DMTS on organisms.Within the realm of scientific research, DMTS finds significant roles. It acts as a surfactant in cell cultures, demonstrating its efficacy in augmenting cell adhesion and viability. Moreover, it plays a pivotal role in protein purification, facilitating protein solubilization and enhancing purification efficiency. Notably, DMTS extends its utility to bioremediation, aiding in the mitigation of heavy metal toxicity in aquatic environments.


Dodecyl Methanethiosulfonate (CAS 355803-77-9) References

  1. Control of the conductance of engineered protein nanopores through concerted loop motions.  |  Zhuang, T. and Tamm, LK. 2014. Angew Chem Int Ed Engl. 53: 5897-902. PMID: 24777684
  2. Planar Supported Membranes with Mobile SNARE Proteins and Quantitative Fluorescence Microscopy Assays to Study Synaptic Vesicle Fusion.  |  Kiessling, V., et al. 2017. Front Mol Neurosci. 10: 72. PMID: 28360838
  3. Reconstitution of calcium-mediated exocytosis of dense-core vesicles.  |  Kreutzberger, AJB., et al. 2017. Sci Adv. 3: e1603208. PMID: 28776026
  4. In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.  |  Kreutzberger, AJB., et al. 2019. Nat Commun. 10: 3904. PMID: 31467284
  5. Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.  |  Kreutzberger, AJB., et al. 2020. Elife. 9: PMID: 33164744

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dodecyl Methanethiosulfonate, 50 mg

sc-211372
50 mg
$333.00